Journal ArticleDOI
Design, synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents.
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The cyclopenta[b]quinoline derivative 9 and the acridine derivative 13 showed remarkable MIC values against the rifampin resistant strain and can be considered a new lead compound.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2014-02-12. It has received 54 citations till now. The article focuses on the topics: Acridine & Quinoline.read more
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Recent developments in the synthesis and biological activity of acridine/acridone analogues
TL;DR: This survey describes acridine and acridone derivatives reported since 2013, methods of their synthesis and their potential clinical applications, as well as investigating their clinical application in Alzheimer's disease and other diseases.
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Sustainable synthesis of N-heterocycles in water using alcohols following the double dehydrogenation strategy
TL;DR: In this paper, the authors described the first example of synthesis of pharmaceutically relevant N-heterocycles like substituted quinolines, acridines and 1,8-naphthyridines in water under air using alcohols in presence of a new water soluble Ir-complex.
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ONO pincer type Pd(II) complexes: synthesis, crystal structure and catalytic activity towards C-2 arylation of quinoline scaffolds
TL;DR: In this article, four palladium(II) complexes featuring ONO pincer type hydrazone ligands were synthesized and characterized by spectroscopic and single-crystal XRD analysis.
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Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors
TL;DR: The typical compound 8p could penetrate A549 cancer cells efficiently and induce A549 cells apoptosis through caspase-dependent intrinsic pathway and arrest A549-cells at the G2/M phase.
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Pd catalyzed facile synthesis of cyclopenta[b]quinolin-1-one via sequential Sonogashira coupling and annulation. An unusual mode of ring closure, using sulphur as a soft nucleophile
TL;DR: Pd mediated one pot sequential Sonogashira coupling followed by annulation using o-alkynyl aldehyde is reported, delivering cyclopenta[b]quinolin-1-one in high yields and conducting chemoselective transformations across annulated precursors.
References
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Recent Advances in the Friedländer Reaction
José Marco-Contelles,Elena Pérez-Mayoral,Abdelouahid Samadi,Maria do Carmo Carreiras,Elena Soriano +4 more
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Ionic Liquid-Promoted Regiospecific Friedlander Annulation: Novel Synthesis of Quinolines and Fused Polycyclic Quinolines
TL;DR: On screening, 1-butylimidazolium tetrafluoroborate [Hbim]BF4 was found to be the best ionic liquid for the heteroannulation reaction, and the reasons to this effect are well explained.
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Recent advances in antitubercular natural products.
TL;DR: The present review covers literature published during the last five years about those naturally occurring compounds with reported growth inhibitory activity in vitro towards sensitive and resistant M. tuberculosis strains and includes a special section for those natural products that specifically target genes or enzymes of M.culosis.
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Microwave-assisted Friedländer synthesis of quinolines derivatives as potential antiparasitic agents
TL;DR: A series of substituted quinolines was developed via the Friedlander reaction employing microwave irradiation (MW), in the presence of a catalytic amount of hydrochloric acid.
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Ring-substituted quinolines as potential anti-tuberculosis agents.
TL;DR: In vitro antimycobacterial properties of ring-substituted quinolines constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains are reported, comparable to first line anti-tuberculosis drug, isoniazid.