S
Silvia Giampieri
Researcher at King's College London
Publications - 10
Citations - 1390
Silvia Giampieri is an academic researcher from King's College London. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 8, co-authored 9 publications receiving 1321 citations. Previous affiliations of Silvia Giampieri include Randall Division of Cell and Molecular Biophysics & London Research Institute.
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Journal ArticleDOI
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility.
TL;DR: It is demonstrated that TGFβ signalling is transiently and locally activated in motile single cells and essential for blood-borne metastasis as breast cancer cells spread.
Journal ArticleDOI
A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis
Ulrike Philippar,Evanthia T. Roussos,Matthew G. Oser,Hideki Yamaguchi,Hideki Yamaguchi,Hyung-Do Kim,Silvia Giampieri,Yarong Wang,Sumanta Goswami,Sumanta Goswami,Jeffrey B. Wyckoff,Douglas A. Lauffenburger,Erik Sahai,Erik Sahai,John S. Condeelis,Frank B. Gertler +15 more
TL;DR: It is shown that Mena and Mena(INV) promote carcinoma cell motility and invasiveness in vivo and in vitro, and increase lung metastasis and EGF-induced membrane protrusion of tumor cells.
A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis
Ulrike Philippar,Evanthia T. Roussos,Matthew G. Oser,Hideki Yamaguchi,Hideki Yamaguchi,Hyung-Do Kim,Silvia Giampieri,Yarong Wang,Sumanta Goswami,Sumanta Goswami,Jeffrey B. Wyckoff,Douglas A. Lauffenburger,Erik Sahai,Erik Sahai,John S. Condeelis,Frank B. Gertler +15 more
TL;DR: In this paper, Mena and Mena(INV) were shown to promote carcinoma cell motility and invasiveness in vivo and in vitro, and increase lung metastasis.
Journal ArticleDOI
Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18.
Silvia Giampieri,Alan Storey +1 more
TL;DR: Results show that unrepaired DNA damage can be observed in UV-B-irradiated cells expressing the E6 protein of HPV types found in cervical and epithelial cancers, and such cells have the ability to overcome the G1 cell cycle checkpoint induced as a result of un repaired DNA.
Journal ArticleDOI
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells.
Susan C Short,Silvia Giampieri,M. Worku,Marisa Alcaide-German,George Sioftanos,S. Bourne,Ka Ian Lio,M Shaked-Rabi,Christine Martindale +8 more
TL;DR: Rad51-dependent repair makes a significant contribution to DNA repair in glioma cells and contributes to resistance to both XR and TMZ, and agents targeting Rad51- dependent repair would be effective adjuvants in standard combination regimens.