Silvia Regina Rogatto

TL;DR: The preliminary findings suggested that abnormal CDH1 methylation occurs in high frequencies in infiltrating breast cancers associated with a decrease in E-cadherin expression in a subgroup of cases characterized by loss of expression of other important genes to the mammary carcinogenesis process, probably due to the disruption of the mechanism of maintenance of DNA methylation in tumoral cells.

TL;DR: Open reading frame expressed sequences tags (ORESTES) as discussed by the authors differ from conventional ESTs by providing sequence data from the central protein coding portion of transcripts, which can be used for gene discovery and shotgun transcript sequence generation.

TL;DR: A set of 250,000 cDNAs that represent partial expressed gene sequences and that are biased toward the central coding regions of the resulting transcripts, termed ORF expressed sequence tags (ORESTES), defined 48 transcribed sequences on chromosome 22 not defined by other sequences.

TL;DR: A pilot genome-wide screen for CNVs in a cohort of patients with early-onset obsessive-compulsive disorder and 12 mentally healthy individuals found a small rare paternal inherited microdeletion in one male patient with very early onset OCD, which supports the hypothesis of a complex network of several genes expressed in the brain contributing for the genetic risk of OCD.

TL;DR: The combination of circulating mRNA and miRNA was useful for the diagnosis and prognosis of PCa.