Paulo L. Ho

TL;DR: The complete genome sequence of X. fastidiosa clone 9a5c is reported, providing direct evidence of phage-mediated horizontal gene transfer and indicating that the molecular basis for bacterial pathogenicity is both conserved and independent of host.

TL;DR: By analyzing automated Gene Ontology assignments, this work provides a detailed view of important S. mansoni biological systems, including characterization of metazoa-specific and eukarya-conserved genes, and identifies novel proteins to be investigated as vaccine candidates and potential drug targets.

TL;DR: Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis.

TL;DR: The construction of a vector derived from pET3-His and pRSET plasmids for the expression and purification of recombinant proteins in Escherichia coli based on T7 phage RNA polymerase, which enables the expression of a fusion protein with a minimal amino-terminal hexa-histidine affinity tag.

TL;DR: Novel features of the genome sequence of Leptospira interrogans serovar Copenhageni, a highly invasive spirochete, are reported, revealing the presence of a competent transport system with 13 families of genes encoding for major transporters including a three-member component efflux system compatible with the long-term survival of this organism.