S
Simeone Marino
Researcher at University of Michigan
Publications - 56
Citations - 5042
Simeone Marino is an academic researcher from University of Michigan. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 29, co-authored 53 publications receiving 4269 citations. Previous affiliations of Simeone Marino include Sapienza University of Rome.
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A Methodology For Performing Global Uncertainty And Sensitivity Analysis In Systems Biology
TL;DR: This work develops methods for applying existing analytical tools to perform analyses on a variety of mathematical and computer models and provides a complete methodology for performing these analyses, in both deterministic and stochastic settings, and proposes novel techniques to handle problems encountered during these types of analyses.
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Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms
Joshua T. Mattila,Olabisi Ojo,Diane Kepka-Lenhart,Simeone Marino,Jin Hee Kim,Seok Yong Eum,Laura E. Via,Clifton E. Barry,Edwin Klein,Denise E. Kirschner,Sidney M. Morris,Philana Ling Lin,JoAnne L. Flynn +12 more
TL;DR: The combination of phenotypic and functional markers support that granulomas have organized microenvironments that balance antimicrobial anti-inflammatory responses to limit pathology in the lungs.
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Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.
Hannah P. Gideon,Jia Yao Phuah,Amy J. Myers,Bryan D. Bryson,Mark Rodgers,M. Teresa Coleman,Pauline Maiello,Tara Rutledge,Simeone Marino,Sarah M. Fortune,Denise E. Kirschner,Philana Ling Lin,JoAnne L. Flynn +12 more
TL;DR: The results support that each granuloma within an individual host is independent with respect to total cell numbers, proportion of T cells, pattern of cytokine response, and bacterial burden, and the spectrum of these components overlaps greatly amongst animals with different clinical status.
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Mathematical modeling of primary succession of murine intestinal microbiota
TL;DR: The next-generation sequencing and mathematical models were used to quantify the interpopulation interactions that occurred after a germfree mouse was inoculated with a murine microbiome, and suggested a lack of mutualistic interactions within the community.
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The human immune response to Mycobacterium tuberculosis in lung and lymph node.
TL;DR: This work extends a temporal mathematical model that qualitatively and quantitatively characterizes the cellular and cytokine control network during infection to a two compartmental model to capture the important processes of cellular activation and priming that occur between the lung and the nearest draining lymph node.