Simeone Marino

TL;DR: This work develops methods for applying existing analytical tools to perform analyses on a variety of mathematical and computer models and provides a complete methodology for performing these analyses, in both deterministic and stochastic settings, and proposes novel techniques to handle problems encountered during these types of analyses.

TL;DR: The combination of phenotypic and functional markers support that granulomas have organized microenvironments that balance antimicrobial anti-inflammatory responses to limit pathology in the lungs.

TL;DR: The results support that each granuloma within an individual host is independent with respect to total cell numbers, proportion of T cells, pattern of cytokine response, and bacterial burden, and the spectrum of these components overlaps greatly amongst animals with different clinical status.

TL;DR: The next-generation sequencing and mathematical models were used to quantify the interpopulation interactions that occurred after a germfree mouse was inoculated with a murine microbiome, and suggested a lack of mutualistic interactions within the community.

TL;DR: This work extends a temporal mathematical model that qualitatively and quantitatively characterizes the cellular and cytokine control network during infection to a two compartmental model to capture the important processes of cellular activation and priming that occur between the lung and the nearest draining lymph node.