S
Simon A. Chanas
Researcher at University of Edinburgh
Publications - 14
Citations - 1999
Simon A. Chanas is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Kaposi's sarcoma-associated herpesvirus & Glutathione. The author has an hindex of 11, co-authored 14 publications receiving 1893 citations. Previous affiliations of Simon A. Chanas include University of Dundee & University of Birmingham.
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Journal Article
The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes
Michael McMahon,Ken Itoh,Masayuki Yamamoto,Simon A. Chanas,Colin J. Henderson,Lesley I. McLellan,C. Roland Wolf,Christophe Cavin,John D. Hayes +8 more
TL;DR: In the small intestine, the constitutive level of NQO1 is lower in the Nrf2-/- mouse, and immunoblotting showed that induction of the oxidoreductase was substantially diminished in the mutant mouse.
Journal ArticleDOI
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.
Simon A. Chanas,Qing Jiang,Michael McMahon,Gail K. McWalter,Lesley I. McLellan,Clifford R. Elcombe,Colin J. Henderson,C. Roland Wolf,Graeme J. Moffat,Ken Itoh,Masayuki Yamamoto,John D. Hayes +11 more
TL;DR: The increased sensitivity of Nrf2(-/-) mice to xenobiotics can be partly attributed to a loss in constitutive expression of multiple GSH-dependent enzymes, which causes a reduction in intrinsic detoxification capacity in the KO animal and probably accounts for their failure to adapt to chronic exposure to chemical and oxidative stress.
Journal ArticleDOI
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.
John D. Hayes,Simon A. Chanas,Colin J. Henderson,Michael McMahon,C. Sun,G J Moffat,C R Wolf,Masayuki Yamamoto +7 more
TL;DR: Significantly, residual induction of GST by antioxidants is apparent in the Nrf2 mutant mouse, indicating the existence of an alternative mechanism of gene activation.
Journal ArticleDOI
Corneal development, limbal stem cell function, and corneal epithelial cell migration in the Pax6+/- mouse
TL;DR: Degeneration of the corneal surface in aniridia-related keratopathy relates to both a deficiency within the limbal stem cell niche and nonautonomous diversion ofCorneal epithelial cell migration.
Journal Article
Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver
Vincent P. Kelly,Elizabeth M. Ellis,Margaret M. Manson,Simon A. Chanas,Graeme J. Moffat,Ronald McLeod,David J. Judah,Gordon E. Neal,John D. Hayes +8 more
TL;DR: The data suggest that consumption of a CMRN-containing diet provides substantial protection against the initiation of AFB1 hepatocarcinogenesis in the rat, and the ability of the benzopyrone to inhibit either AFB1-initiated preneoplastic nodules or AFB1- initiated liver tumors was investigated.