E
Elizabeth M. Ellis
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 62
Citations - 1935
Elizabeth M. Ellis is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Reductase & Aldo-keto reductase. The author has an hindex of 24, co-authored 62 publications receiving 1799 citations. Previous affiliations of Elizabeth M. Ellis include University of Florida & University of Strathclyde.
Papers
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Journal ArticleDOI
Reactive carbonyls and oxidative stress: potential for therapeutic intervention.
TL;DR: The metabolism of reactive carbonyls is described and the potential for manipulating levels of carbonyl-metabolizing enzymes through chemical intervention is discussed.
Journal ArticleDOI
Terahertz underdamped vibrational motion governs protein-ligand binding in solution
David A. Turton,Hans Martin Senn,Thomas Harwood,Adrian J. Lapthorn,Elizabeth M. Ellis,Klaas Wynne +5 more
TL;DR: Underdamped delocalized vibrational modes in the terahertz frequency domain are identified and shown to blue-shift and strengthen upon inhibitor binding, demonstrating that the ligand-binding coordinate in proteins is underdamped and not simply solvent-controlled as previously assumed.
Journal Article
Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver
Vincent P. Kelly,Elizabeth M. Ellis,Margaret M. Manson,Simon A. Chanas,Graeme J. Moffat,Ronald McLeod,David J. Judah,Gordon E. Neal,John D. Hayes +8 more
TL;DR: The data suggest that consumption of a CMRN-containing diet provides substantial protection against the initiation of AFB1 hepatocarcinogenesis in the rat, and the ability of the benzopyrone to inhibit either AFB1-initiated preneoplastic nodules or AFB1- initiated liver tumors was investigated.
Cellular response to cancer chemopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress.
TL;DR: The mechanism whereby cells sense and respond to the chemical signal(s) generated by chemopreventive blocking agents is discussed, which represents a form of adaptive response.
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Microbial aldo-keto reductases
TL;DR: The aldo-keto reductases (AKR) are a superfamily of enzymes with diverse functions in the reduction of aldehydes and ketones and there is potential for other novel members of this important superfamily to be identified, studied and utilized in this way.