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Simon Monard
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 31
Citations - 4076
Simon Monard is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 18, co-authored 29 publications receiving 3966 citations. Previous affiliations of Simon Monard include Los Alamos National Laboratory & Lincoln's Inn.
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Journal ArticleDOI
Differential Inhibition of Human Immunodeficiency Virus Type 1 Fusion, gp120 Binding, and CC-Chemokine Activity by Monoclonal Antibodies to CCR5
William C. Olson,Gwénaël Rabut,Kirsten A. Nagashima,Diep N. H. Tran,Deborah J. Anselma,Simon Monard,Jeremy P. Segal,Daniah A. D. Thompson,Francis Kajumo,Yong Guo,John P. Moore,Paul J. Maddon,Tatjana Dragic +12 more
TL;DR: Surprisingly, there was no correlation between the ability of a MAb to inhibit HIV-1 fusion-entry and its ability to inhibit either the binding of a gp120-soluble CD4 complex to CCR5 or CC-chemokine activity.
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Genetic Subtype-Independent Inhibition of Human Immunodeficiency Virus Type 1 Replication by CC and CXC Chemokines
Alexandra Trkola,William A. Paxton,Simon Monard,James A. Hoxie,Michael A. Siani,Darren A. Thompson,Lijun Wu,Charles R. Mackay,Richard Horuk,John P. Moore +9 more
TL;DR: There was considerable interisolate variation in the sensitivity of HIV-1 to chemokine inhibition, which was especially pronounced for the CC chemokines and M-tropic strains.
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Long-term maintenance of virus-specific effector memory CD8+ T cells in the lung airways depends on proliferation.
Robert J. Hogan,Linda S. Cauley,Kenneth H. Ely,Tres Cookenham,Alan D. Roberts,Jean W. Brennan,Simon Monard,David L. Woodland +7 more
TL;DR: The mechanisms underlying the persistence of memory CD8+ T cells in the lung airway lumina following recovery from a respiratory virus infection are analyzed and suggest that these cells may be recent immigrants from the lymphoid organs.
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Expression Patterns of the HIV Type 1 Coreceptors CCR5 and CXCR4 on CD4+ T Cells and Monocytes from Cord and Adult Blood
Hongmei Mo,Simon Monard,Henry Pollack,James Ip,Gemma Rochford,Lijun Wu,James A. Hoxie,William Borkowsky,David D. Ho,John P. Moore +9 more
TL;DR: The overall extent of CCR5 expression was reduced in cord blood, compared with adult blood, and IL-2 activation of CD4+ T cells from both cord and adult bloods caused a substantial increase in C CR5 expression, but moderately decreased CXCR4 expression.
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Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells.
Hans M. L. Spiegel,Graham S. Ogg,Elizabeth DeFalcon,Megan E. Sheehy,Simon Monard,Patrick A. J. Haslett,Geraldine M. Gillespie,Sean M. Donahoe,Henry Pollack,William Borkowsky,Andrew J. McMichael,Douglas F. Nixon +11 more
TL;DR: Virus-specific CD8+ T cells can be maintained in the peripheral circulation at high frequency in the absence of circulating peripheral CD4-cell count, but these cells may lack direct effector activity.