S
Simon N. Stacey
Researcher at National Health Service
Publications - 22
Citations - 1536
Simon N. Stacey is an academic researcher from National Health Service. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 18, co-authored 22 publications receiving 1497 citations.
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Journal ArticleDOI
A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer
L. K. Borysiewicz,Alison Nina Fiander,M. Nimako,Stephen Man,Gavin William Grahame Wilkinson,D. Westmoreland,A. S. Evans,Malcolm Adams,Simon N. Stacey,Mike Boursnell,E. Rutherford,Julian Hickling,Stephen Charles Inglis +12 more
TL;DR: Examination of the clinical and environmental safety and immunogenicity in the first clinical trial of a live recombinant vaccinia virus expressing the E6 and E7 proteins of HPV 16 and 18 found vaccination resulted in no significant clinical side-effects and there was no environmental contamination by live TA-HPV.
Journal Article
Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer.
Andreas M. Kaufmann,Peter L. Stern,Elaine Rankin,Harald Sommer,Volkmar Nuessler,Achim Schneider,Malcolm Adams,Toli S Onon,Thomas Bauknecht,Uwe Wagner,Karlijn Kroon,Julian Hickling,Christopher M. Boswell,Simon N. Stacey,Henry C Kitchener,Jennifer Gillard,Jantien Wanders,John St C Roberts,Heinz Zwierzina +18 more
TL;DR: This study confirmed the safety and immunogenicity of the vaccine in a proportion of those patients vaccinated with TA-HPV, a live recombinant vaccinia virus expressing modified forms of the HPV-16 and -18 E6 and E7 proteins.
Journal ArticleDOI
Leaky Scanning Is the Predominant Mechanism for Translation of Human Papillomavirus Type 16 E7 Oncoprotein from E6/E7 Bicistronic mRNA
Simon N. Stacey,Deborah Jordan,Andrew J.K. Williamson,Michael D Brown,Joanna H Coote,John R. Arrand +5 more
TL;DR: The findings suggest that the E 6 region of HPV-16 comprises features that sponsor both translation of the E6 protein and enhancement of translation at a downstream site, and a model in which E7 translation is facilitated by an extreme degree of leaky scanning, requiring the negotiation of 13 upstream AUGs.
Journal ArticleDOI
Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes in women with cervical neoplasia
Hetty J. Bontkes,Tanja D. de Gruijl,Adrie J.C. van den Muysenberg,René H.M. Verheijen,Marij J. Stukart,Chris J.L.M. Meijer,Rik J. Scheper,Simon N. Stacey,Margaret F. Duggan-Keen,Peter L. Stern,Stephen Man,Leszek K. Borysiewicz,Jan M. M. Walboomers +12 more
TL;DR: It is demonstrated that HPV 16 oncogene‐specific mCTLp are present in women with HPV 16‐positive CIN prior to any intervention, and the role of naturally occurring m CTLp in the protection against HPV‐associated cervical neoplasia remains to be established.
Journal ArticleDOI
Translation of the human papillomavirus type 16 E7 oncoprotein from bicistronic mRNA is independent of splicing events within the E6 open reading frame.
Simon N. Stacey,Deborah Jordan,P J Snijders,Mike Mackett,Jan M. M. Walboomers,John R. Arrand +5 more
TL;DR: It was found, unexpectedly, that E7 protein could be translated from full-length bicistronic E6-E7 mRNAs, and a model in which the failure of 40S ribosomal initiation complexes to recognize the E6 AUG renders them capable of proceeding efficiently to translate E7 was supported.