Madeleine E. Lemieux

TL;DR: In this paper, a small-molecule bromodomain inhibitor, JQ1, was used to identify BET proteins as regulatory factors for c-Myc oncoprotein.

TL;DR: It is shown that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors, and how down-regulating these two classes of damage-responsive mammalian factors may favor long lifespan under certain environmental conditions, such as calorie restriction is speculated.

TL;DR: It is shown that Sirt1 positively regulates insulin secretion in pancreatic β cells, and regulates UCP2 in β cells to affect insulin secretion, which causes the defect in glucose-stimulated insulin secretion.

TL;DR: In this article, Sirt1 positively regulates insulin secretion in pancreatic b cells and showed that the up-regulation of UCP2 is associated with a failure of cells to increase ATP levels after glucose stimulation.

TL;DR: No evidence for failure of gene silencing is found in sir2α null animals, suggesting that either SIR2α has a different role in mammals than it does in Saccharomyces cerevisiae or that its role in genesilencing in confined to a small subset of mammalian genes.