Sina Wäldchen

TL;DR: This work applied single-molecule localization microscopy conditions and tested the influence of irradiation intensity, illumination-mode, wavelength, light-dose, temperature and fluorescence labeling on the survival probability of different cell lines 20–24 hours after irradiation.

TL;DR: A role for CsrA-FliW in spatiotemporal control of flagella assembly and localization of a dual-function mRNA is suggested and it is revealed that flaA mRNA is expressed and localized at the poles of elongating cells.

TL;DR: It is indicated that Cdh13 deficiency affects the cell density of the developing DR and the posterior innervation of the prefrontal cortex (PFC), and therefore might be involved in the migration, axonal outgrowth and terminal target finding of DR 5-HT neurons.

TL;DR: Results show that exclusive inactivation of CDH13 in 5-HT neurons selectively increases 5- HT neuron density in the embryonic dorsal raphe, with persistence into adulthood, and serotonergic innervation of the developing prefrontal cortex.

TL;DR: This work describes an efficient generation of functionally active neurons from hiPSCs displaying 5-HT specification by modification of a previously reported protocol and describes the heterogeneous nature of dorsal and median raphe nuclei to facilitate examining the association of serotonergic neuron subpopulations with neuropsychiatric disorders.