S
Sinaye Ngcapu
Researcher at Centre for the AIDS Programme of Research in South Africa
Publications - 42
Citations - 409
Sinaye Ngcapu is an academic researcher from Centre for the AIDS Programme of Research in South Africa. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 7, co-authored 27 publications receiving 245 citations. Previous affiliations of Sinaye Ngcapu include University of KwaZulu-Natal.
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Journal ArticleDOI
Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.
Lyle R. McKinnon,Lyle R. McKinnon,Lyle R. McKinnon,Lenine J. P. Liebenberg,Lenine J. P. Liebenberg,Nonhlanhla Yende-Zuma,Derseree Archary,Derseree Archary,Sinaye Ngcapu,Sinaye Ngcapu,Aida Sivro,Aida Sivro,Aida Sivro,Nico J. D. Nagelkerke,Jose Gerardo Garcia Lerma,Angela D. M. Kashuba,Lindi Masson,Lindi Masson,Leila E. Mansoor,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Jo-Ann S. Passmore +25 more
TL;DR: A post hoc prospective analysis of results from the CAPRISA 004 trial for 1% tenofovir gel, one of the first trials to demonstrate protection against HIV infection, found that reducing genital inflammation in women may augment HIV prevention efforts.
Journal ArticleDOI
Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection
Lindi Masson,Kelly B. Arnold,Francesca Little,Koleka Mlisana,David A. Lewis,Nonhlanhla N. Mkhize,Hoyam Gamieldien,Sinaye Ngcapu,Leigh F. Johnson,Douglas A. Lauffenburger,Quarraisha Abdool Karim,Salim S. Abdool Karim,Jo-Ann S. Passmore +12 more
TL;DR: In this article, a multivariate profile of seven cytokines (interleukin (IL)-1α, IL-1β, tumour necrosis factor-β, IL4, fractalkine, macrophage-derived chemokine, and interferon-γ) was used to identify cytokine profiles associated with STIs/BV.
Journal ArticleDOI
Lower concentrations of chemotactic cytokines and soluble innate factors in the lower female genital tract associated with the use of injectable hormonal contraceptive.
Sinaye Ngcapu,Lindi Masson,Sengeziwe Sibeko,Lise. Werner,Lyle R. McKinnon,Koleka Mlisana,Muki Shey,Natasha Samsunder,Salim S. Abdool Karim,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Jo-Ann S. Passmore +13 more
TL;DR: Injectable HC use was broadly associated with an immunosuppressive female genital tract innate immune profile, and the relationship between injectableHC use and STI or HIV risk is yet to be resolved.
Journal ArticleDOI
Transmission dynamics of SARS-CoV-2 within-host diversity in two major hospital outbreaks in South Africa
James Emmanuel San,Sinaye Ngcapu,Sinaye Ngcapu,Aquillah M. Kanzi,Houriiyah Tegally,Vagner Fonseca,Jennifer Giandhari,Eduan Wilkinson,Chase W. Nelson,Chase W. Nelson,Werner Smidt,Anmol M. Kiran,Anmol M. Kiran,Benjamin Chimukangara,Sureshnee Pillay,Lavanya Singh,Maryam Fish,Inbal Gazy,Darren P. Martin,Khulekani Sedwell Khanyile,Richard J Lessells,Tulio de Oliveira,Tulio de Oliveira +22 more
TL;DR: In this article, the authors used high-throughput sequencing whole-genome data coupled with bottleneck analysis to retrace the pathways of viral transmission in two nosocomial outbreaks that were previously characterised by epidemiological and phylogenetic methods.
Journal ArticleDOI
Role of semen in altering the balance between inflammation and tolerance in the female genital tract: does it contribute to HIV risk?
Cosnet L. Rametse,Abraham J. Olivier,Lindi Masson,Shaun L. Barnabas,Lyle R. McKinnon,Sinaye Ngcapu,Lenine J. P. Liebenberg,Shameem Z. Jaumdally,Clive M. Gray,Heather B. Jaspan,Jo-Ann S. Passmore +10 more
TL;DR: This work discusses the constituents of semen that may increase the risk for HIV infection in women and highlights the importance of knowing the carrier and removal status of these molecules.