N
Nonhlanhla Yende-Zuma
Researcher at Centre for the AIDS Programme of Research in South Africa
Publications - 70
Citations - 1161
Nonhlanhla Yende-Zuma is an academic researcher from Centre for the AIDS Programme of Research in South Africa. The author has contributed to research in topics: Medicine & Tuberculosis. The author has an hindex of 16, co-authored 57 publications receiving 793 citations. Previous affiliations of Nonhlanhla Yende-Zuma include University of KwaZulu-Natal & South African Medical Research Council.
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Journal ArticleDOI
Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women.
Lyle R. McKinnon,Lyle R. McKinnon,Lyle R. McKinnon,Lenine J. P. Liebenberg,Lenine J. P. Liebenberg,Nonhlanhla Yende-Zuma,Derseree Archary,Derseree Archary,Sinaye Ngcapu,Sinaye Ngcapu,Aida Sivro,Aida Sivro,Aida Sivro,Nico J. D. Nagelkerke,Jose Gerardo Garcia Lerma,Angela D. M. Kashuba,Lindi Masson,Lindi Masson,Leila E. Mansoor,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Jo-Ann S. Passmore +25 more
TL;DR: A post hoc prospective analysis of results from the CAPRISA 004 trial for 1% tenofovir gel, one of the first trials to demonstrate protection against HIV infection, found that reducing genital inflammation in women may augment HIV prevention efforts.
Journal ArticleDOI
The Immune Reconstitution Inflammatory Syndrome After Antiretroviral Therapy Initiation in Patients With Tuberculosis: Findings From the SAPiT Trial
Kogieleum Naidoo,Nonhlanhla Yende-Zuma,Nesri Padayatchi,K Naidoo,Niraksha. Jithoo,Gonasagrie Nair,Sheila Bamber,Santhana Gengiah,Wafaa. El-Sadr,Gerald Friedland,Salim S. Abdool Karim +10 more
TL;DR: Initiation of ART in early stages of tuberculosis treatment resulted in significantly higher IRIS rates, longer time to resolution, and more severe cases of IRIS requiring hospitalization.
Journal ArticleDOI
Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes
Aida Sivro,Aida Sivro,Alexandra Schuetz,Daniel J. Sheward,Vineet Joag,Sergey Yegorov,Lenine J. P. Liebenberg,Nonhlanhla Yende-Zuma,Andrew T. Stalker,Ruth S. Mwatelah,Philippe Selhorst,Nigel Garrett,Natasha Samsunder,Anisha Balgobin,Fatima Nawaz,Claudia Cicala,James Arthos,Anthony S. Fauci,AO Anzala,Joshua Kimani,Joshua Kimani,Bernard S. Bagaya,Bernard S. Bagaya,Noah Kiwanuka,Noah Kiwanuka,Carolyn Williamson,Carolyn Williamson,Rupert Kaul,Rupert Kaul,Jo-Ann S. Passmore,Jo-Ann S. Passmore,Nittaya Phanuphak,Jintanat Ananworanich,Jintanat Ananworanich,Aftab A. Ansari,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Lyle R. McKinnon,Lyle R. McKinnon,Lyle R. McKinnon,Rv study groups +42 more
TL;DR: This study shows that pre-HIV infection frequencies of α4β7+ peripheral blood CD4+ T cells, independent of other T cell phenotypes and genital inflammation, were associated with increased rates of HIV acquisition in South African women and supported further evaluation of targeting α4 β7 integrin as a clinical intervention during HIV infection.
Journal ArticleDOI
Case report: mechanisms of HIV elite control in two African women.
Yumna. Moosa,Ramla F. Tanko,Veron Ramsuran,Veron Ramsuran,Veron Ramsuran,Ravesh Singh,Mashudu Madzivhandila,Nonhlanhla Yende-Zuma,Melissa-Rose Abrahams,Philippe Selhorst,Kamini Gounder,Penny L. Moore,Penny L. Moore,Carolyn Williamson,Carolyn Williamson,Salim S. Abdool Karim,Salim S. Abdool Karim,Nigel Garrett,Wendy A. Burgers +18 more
TL;DR: The atypical finding of pre-infection HIV-specific immunity in one elite controller, that may have contributed to very early viral control is made, highlighting the importance of studying HIV controllers in high incidence settings.
Journal ArticleDOI
Trends in HIV Prevalence in Pregnant Women in Rural South Africa.
Ayesha B. M. Kharsany,Janet A. Frohlich,Nonhlanhla Yende-Zuma,Gethwana Mahlase,Natasha Samsunder,Rachael C. Dellar,May. Zuma-Mkhonza,Salim S. Abdool Karim,Quarraisha Abdool Karim +8 more
TL;DR: Notwithstanding the encouraging decline in teenagers, the ongoing high HIV prevalence in pregnant women in this rural community, despite prevention and treatment programs, is deeply concerning and targeted interventions for teenagers are needed to impact this HIV epidemic trajectory.