Sirisha Chakka

TL;DR: It is found that RAF node knockdown best differentiated KRAS mutant and KRAS WT cancer cells, suggesting RAF kinases are key oncoeffectors for KRAS addiction, and cotargeting the RAF, RAC, and autophagy pathways can improve the capture of KRAS dependency better than targeting RAF alone.

TL;DR: It is found that all five N SD2 inhibitors bind the catalytic SET domain and one exhibited apparent activity in cells, validating the workflow and providing a template for identifying selective NSD2 inhibitors.

TL;DR: It is confirmed that small-molecule inhibition of SRC or BCL2L1, in combination with TRAIL, sensitizes breast cancer cells to TRAIL-induced apoptosis, including cell lines resistant to TRAil-induced cytotoxicity.

TL;DR: In this paper, the authors performed an unbiased genome-wide RNAi screen in SLFN11-WT and -knockout (KO) cells and found that inactivation of Ataxia Telangiectasia- and Rad3-related (ATR), CHK1, BRCA2, and RPA1 overcome chemoresistance to camptothecin (CPT) in cancer cells.

TL;DR: The results provide a strong rationale for clinical investigation of CHK1 and BRD4 co-inhibition, especially for HGSOC patients withBRD4 overexpression, and increase the anti-tumor activity of this pathway.