J
Ji Luo
Researcher at National Institutes of Health
Publications - 97
Citations - 18411
Ji Luo is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Phosphoinositide 3-kinase. The author has an hindex of 41, co-authored 74 publications receiving 16650 citations. Previous affiliations of Ji Luo include Howard Hughes Medical Institute & Beth Israel Deaconess Medical Center.
Papers
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Journal ArticleDOI
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Shuhei Matsuoka,Bryan A. Ballif,Agata Smogorzewska,Agata Smogorzewska,E. Robert McDonald,Kristen E. Hurov,Ji Luo,Corey E. Bakalarski,Zhenming Zhao,Nicole L. Solimini,Yaniv Lerenthal,Yosef Shiloh,Steven P. Gygi,Stephen J. Elledge +13 more
TL;DR: A large-scale proteomic analysis of proteins phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR is performed and more than 900 regulated phosphorylation sites encompassing over 700 proteins are identified.
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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
TL;DR: In light of the recent advances in understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, the exciting therapeutic opportunities for targeting this pathway to treat these diseases are discussed.
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Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
TL;DR: Evidence is presented for a large class of non-oncogenes that are essential for cancer cell survival and present attractive drug targets and theoretical considerations for combining orthogonal cancer therapies are provided.
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Drugging the undruggable Ras: mission possible?
TL;DR: This Review summarizes the progress and the promise of five key approaches for the development of RAS-inhibitory molecules and addresses the issue of whether blocking RAS membrane association is a viable approach.
Journal Article
Targeting the PI3K-Akt pathway in human cancer : Rationale and promise
TL;DR: In this paper, the authors regret that many of the many laboratories whose contribution to this field could not be discussed or cited due to space limitations, many primary references were omitted, and they also regret that they did not cite all the laboratories whose contributions were discussed and cited.