S
Siu-Ying Lau
Researcher at University of Hong Kong
Publications - 24
Citations - 1494
Siu-Ying Lau is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Virus & Influenza A virus subtype H5N1. The author has an hindex of 13, co-authored 23 publications receiving 1375 citations. Previous affiliations of Siu-Ying Lau include Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Journal ArticleDOI
Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome
Yu Chen,Weifeng Liang,Shigui Yang,Nanping Wu,Hainv Gao,Jifang Sheng,Hangping Yao,Jianer Wo,Qiang Fang,Dawei Cui,Yongcheng Li,Xing Yao,Yun-Tao Zhang,Haibo Wu,Shufa Zheng,Hongyan Diao,Shichang Xia,Yanjun Zhang,Kwok-Hung Chan,Hoi-Wah Tsoi,Jade Lee-Lee Teng,Wenjun Song,Pui Wang,Siu-Ying Lau,Min Zheng,Jasper Fuk-Woo Chan,Kelvin K. W. To,Honglin Chen,Lanjuan Li,Kwok-Yung Yuen +29 more
TL;DR: Cross species poultry-to-person transmission of this new reassortant H7N9 virus is associated with severe pneumonia and multiorgan dysfunction in human beings and monitoring of the viral evolution and further study of disease pathogenesis will improve disease management, epidemic control, and pandemic preparedness.
Journal ArticleDOI
The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication
Wenjun Song,Pui Wang,Bobo Wing-Yee Mok,Siu-Ying Lau,Xiaofeng Huang,Wai-Lan Wu,Min Zheng,Xi Wen,Shigui Yang,Yu Chen,Lanjuan Li,Kwok-Yung Yuen,Honglin Chen +12 more
TL;DR: PB2-K526R interacts with nuclear export protein and the results suggest that it contributes to enhance replication for certain influenza virus subtypes, particularly in combination with 627K.
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Avian-Origin Influenza A(H7N9) Infection in Influenza A(H7N9)–Affected Areas of China: A Serological Study
Shigui Yang,Yu Chen,Dawei Cui,Hangping Yao,Jianzhou Lou,Zhaoxia Huo,Guoliang Xie,Fei Yu,Shufa Zheng,Yida Yang,Yixin Zhu,Xiaoqing Lu,Xiaoli Liu,Siu-Ying Lau,Jasper Fuk-Woo Chan,Kelvin K. W. To,Kwok-Yung Yuen,Honglin Chen,Lanjuan Li +18 more
TL;DR: Fourteen days after symptom onset, elevated levels of antibodies to A(H7N9) were found in 65.8% of patients who survived but in only 28.6% of those who died, suggesting that the presence of antibodies may improve clinical outcome in infected patients.
Journal ArticleDOI
Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007
Wai Lan Wu,Yixin Chen,Pui Wang,Wenjun Song,Siu-Ying Lau,J. M. Rayner,Gavin J. D. Smith,Robert G. Webster,J. S. Malik Peiris,Tianwei Lin,Tianwei Lin,Ningshao Xia,Yi Guan,Yi Guan,Honglin Chen,Honglin Chen +15 more
TL;DR: Modification of some of these genetic variations produced marked improvement to the immunogenicity and cross-reactivity of H5N1 strains in assays utilizing monoclonal antibodies and ferret antisera, suggesting that these sites represent antigenically significant amino acids.
Journal ArticleDOI
The NS1 Protein of Influenza A Virus Interacts with Cellular Processing Bodies and Stress Granules through RNA-Associated Protein 55 (RAP55) during Virus Infection
Bobo Wing-Yee Mok,Wenjun Song,Pui Wang,H. Tai,Yixin Chen,Min Zheng,Xi Wen,Siu-Ying Lau,Wai Lan Wu,Ken Matsumoto,Kwok-Yung Yuen,Honglin Chen +11 more
TL;DR: Results reveal an interplay between virus and host during virus replication in which NP is targeted to P-bodies/stress granules while NS1 counteracts this host restriction mechanism.