P
Pui Wang
Researcher at University of Hong Kong
Publications - 41
Citations - 2360
Pui Wang is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Virus & Influenza A virus subtype H5N1. The author has an hindex of 17, co-authored 31 publications receiving 2071 citations. Previous affiliations of Pui Wang include Harbin Institute of Technology & Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome
Yu Chen,Weifeng Liang,Shigui Yang,Nanping Wu,Hainv Gao,Jifang Sheng,Hangping Yao,Jianer Wo,Qiang Fang,Dawei Cui,Yongcheng Li,Xing Yao,Yun-Tao Zhang,Haibo Wu,Shufa Zheng,Hongyan Diao,Shichang Xia,Yanjun Zhang,Kwok-Hung Chan,Hoi-Wah Tsoi,Jade Lee-Lee Teng,Wenjun Song,Pui Wang,Siu-Ying Lau,Min Zheng,Jasper Fuk-Woo Chan,Kelvin K. W. To,Honglin Chen,Lanjuan Li,Kwok-Yung Yuen +29 more
TL;DR: Cross species poultry-to-person transmission of this new reassortant H7N9 virus is associated with severe pneumonia and multiorgan dysfunction in human beings and monitoring of the viral evolution and further study of disease pathogenesis will improve disease management, epidemic control, and pandemic preparedness.
Journal ArticleDOI
Distribution of Amantadine-Resistant H5N1 Avian Influenza Variants in Asia
CL Cheung,J. M. Rayner,Gavin J. D. Smith,Pui Wang,T. S. P. Naipospos,Jinxia Zhang,Kwok-Yung Yuen,Robert G. Webster,Robert G. Webster,J. S. Malik Peiris,Yi Guan,Honglin Chen +11 more
TL;DR: The dual mutation motif Leu26Ile-Ser31Asn (leucine-->isoleucine at aa 26 and serine-->asparagine at a aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations.
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Identification of influenza A nucleoprotein as an antiviral target
Richard Y.T. Kao,Dan Yang,Lai-Shan Lau,Wayne H.W. Tsui,LiHong Hu,Jun Dai,Mei-Po Chan,Che-Man Chan,Pui Wang,Bo-Jian Zheng,Jian Sun,Jian-Dong Huang,Jason Madar,GuanHua Chen,Honglin Chen,Yi Guan,Kwok-Yung Yuen +16 more
TL;DR: Nucleozin impeded influenza A virus replication in vitro with a nanomolar median effective concentration (EC50) and protected mice challenged with lethal doses of avian influenza A H5N1 and demonstrated that viral NP is a valid target for the development of small-molecule therapies.
Journal ArticleDOI
The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication
Wenjun Song,Pui Wang,Bobo Wing-Yee Mok,Siu-Ying Lau,Xiaofeng Huang,Wai-Lan Wu,Min Zheng,Xi Wen,Shigui Yang,Yu Chen,Lanjuan Li,Kwok-Yung Yuen,Honglin Chen +12 more
TL;DR: PB2-K526R interacts with nuclear export protein and the results suggest that it contributes to enhance replication for certain influenza virus subtypes, particularly in combination with 627K.
Journal ArticleDOI
Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007
Wai Lan Wu,Yixin Chen,Pui Wang,Wenjun Song,Siu-Ying Lau,J. M. Rayner,Gavin J. D. Smith,Robert G. Webster,J. S. Malik Peiris,Tianwei Lin,Tianwei Lin,Ningshao Xia,Yi Guan,Yi Guan,Honglin Chen,Honglin Chen +15 more
TL;DR: Modification of some of these genetic variations produced marked improvement to the immunogenicity and cross-reactivity of H5N1 strains in assays utilizing monoclonal antibodies and ferret antisera, suggesting that these sites represent antigenically significant amino acids.