S
Siyuan Le
Researcher at Cold Spring Harbor Laboratory
Publications - 5
Citations - 2931
Siyuan Le is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Telomerase & Telomerase reverse transcriptase. The author has an hindex of 5, co-authored 5 publications receiving 2866 citations. Previous affiliations of Siyuan Le include Johns Hopkins University & Johns Hopkins University School of Medicine.
Papers
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Journal ArticleDOI
The RNA component of human telomerase
Junli Feng,Walter Funk,Sy Shi Wang,Scott L. Weinrich,Ariel A. Avilion,Choy-Pik Chiu,Robert Adams,Edwin Chang,Richard C. Allsopp,Jinghua Yu,Siyuan Le,Michael D. West,Calvin B. Harley,William H. Andrews,Carol W. Greider,Bryant Villeponteau +15 more
TL;DR: Human cell lines that expressed hTR mutated in the template region generated the predicted mutant telomerase activity, and cells transfected with an antisense hTR lost telomeric DNA and began to die after 23 to 26 doublings.
Journal ArticleDOI
RAD50 and RAD51 Define Two Pathways That Collaborate to Maintain Telomeres in the Absence of Telomerase
TL;DR: RAD50 and RAD51 define two separate pathways that collaborate to allow cells to survive in the absence of telomerase, and a rad50 rad51 tlc1 triple mutant did not allow the generation of survivors.
Journal ArticleDOI
Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA
TL;DR: The identification of two new proteins that interact with hTR: hStau and L22 are described and it is proposed that these two hTR-associated proteins may play a role in hTR processing, telomerase assembly, or localization in vivo.
Journal ArticleDOI
Telomerase Activity in Human Gliomas
TL;DR: The findings suggest that a novel mechanism in addition to activation of oncogenes and inactivation of tumor suppressor genes may play an important role in tumorigenesis and that the activation of telomerase may correlate with initiation and malignant progression of astrocytic tumors.
Patent
Telomerase-associated proteins
Carol W. Greider,Siyuan Le +1 more
TL;DR: In this paper, a human staufen polypeptide associated with telomerase was described and a method for inhibiting telomerases activity was proposed, which was later shown to be effective.