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Ariel A. Avilion
Researcher at Cold Spring Harbor Laboratory
Publications - 8
Citations - 4991
Ariel A. Avilion is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Telomerase & Telomere. The author has an hindex of 6, co-authored 7 publications receiving 4895 citations. Previous affiliations of Ariel A. Avilion include Stony Brook University.
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Journal ArticleDOI
The RNA component of human telomerase
Junli Feng,Walter Funk,Sy Shi Wang,Scott L. Weinrich,Ariel A. Avilion,Choy-Pik Chiu,Robert Adams,Edwin Chang,Richard C. Allsopp,Jinghua Yu,Siyuan Le,Michael D. West,Calvin B. Harley,William H. Andrews,Carol W. Greider,Bryant Villeponteau +15 more
TL;DR: Human cell lines that expressed hTR mutated in the template region generated the predicted mutant telomerase activity, and cells transfected with an antisense hTR lost telomeric DNA and began to die after 23 to 26 doublings.
Telomere shortening associated withchromosome instability isarrested inimmortal cells whichexpress telomerase activity
Christopher M. Counter,Ariel A. Avilion,Catherine E. LeFeuvrel,Carol W. Greider,Calvin B. Harley,A. Steitz +5 more
TL;DR: The results suggest that chromosomes with short (TTAGGG)n tracts are recombinogenic, critically shortened telomeres may be incompatible with cell proliferation and stabilization of telomere length by telomerase may be required for immortalization.
Journal Article
Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues
Ariel A. Avilion,Mieczyslaw A. Piatyszek,Jyothi Gupta,Jerry W. Shay,Silvia Bacchetti,Carol W. Greider +5 more
TL;DR: Although the hTR levels were somewhat higher in tumor samples compared to nontumor tissues, the level of hTR in a variety of different human tumors did not predict thelevel of telomerase activity in the tumor.
Journal ArticleDOI
Identification of a nonprocessive telomerase activity from mouse cells.
TL;DR: The identification of short telomerase reaction products in mouse extracts suggests that extracts from other organisms may also generate only short products, which may aid in the identification of telomersase activity in organisms where activity has not yet been detected.
Journal ArticleDOI
Tetrahymena telomerase RNA levels increase during macronuclear development.
TL;DR: Investigating whether telomerase RNA levels increase during macronuclear development, since such an increase might be expected during chromosomal fragmentation, paralleled telomersase activity, which increased slightly in mating and starved nonmating cells.