S
Slaheddine Marrakchi
Researcher at University of Sfax
Publications - 37
Citations - 1497
Slaheddine Marrakchi is an academic researcher from University of Sfax. The author has contributed to research in topics: Medicine & Generalized pustular psoriasis. The author has an hindex of 10, co-authored 25 publications receiving 1146 citations.
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Journal ArticleDOI
Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis
Slaheddine Marrakchi,Philippe Guigue,Blair R. Renshaw,Anne Puel,Xue-Yuan Pei,Sylvie Fraitag,Jihen Zribi,Elodie Bal,Céline Cluzeau,Maya Chrabieh,Jennifer E. Towne,Jason Douangpanya,Christian Pons,Sourour Mansour,Valérie Serre,Hafedh Makni,Nadia Mahfoudh,Faiza Fakhfakh,Christine Bodemer,Josué Feingold,Smail Hadj-Rabia,Michel Favre,Emmanuelle Génin,Mourad Sahbatou,Arnold Munnich,Jean-Laurent Casanova,John E. Sims,Hamida Turki,Hervé Bachelez,Asma Smahi +29 more
TL;DR: Aberrant interleukin-36Ra structure and function lead to unregulated secretion of inflammatory cytokines and generalized pustular psoriasis.
Journal ArticleDOI
Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis
Hervé Bachelez,Siew Eng Choon,Slaheddine Marrakchi,A. David Burden,Tsen-Fang Tsai,Akimichi Morita,Hamida Turki,David B. Hall,Michael Shear,Patrick Baum,Steven J. Padula,Christian Thoma +11 more
TL;DR: Seven patients with pustular psoriasis, three with mutations in IL36RN, were treated with a monoclonal antibody against interleukin-36 receptor and had good response to this therapy.
Journal ArticleDOI
Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans.
Franz P.W. Radner,Slaheddine Marrakchi,Peter Kirchmeier,Peter Kirchmeier,Gwang-Jin Kim,Gwang-Jin Kim,Florence Ribierre,Bourane Kamoun,Leila Abid,Michael Leipoldt,Hamida Turki,Werner Schempp,Roland Heilig,Mark Lathrop,Mark Lathrop,Judith Fischer +15 more
TL;DR: Functional analysis of patient skin and in vitro differentiated keratinocytes demonstrated that mutations in CERS3 lead to a disturbed sphingolipid profile with reduced levels of epidermis-specific very long-chain ceramides that interferes with epidermal differentiation.
Journal ArticleDOI
IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases
Marie Tauber,Elodie Bal,Xue-Yuan Pei,Marine Madrange,Amel Khelil,Houria Sahel,Akila Zenati,Mohamed Makrelouf,Khaled Boubridaa,Amel Chiali,Naima Smahi,Farida Otsmane,Bakar Bouajar,Slaheddine Marrakchi,Hamida Turki,Emmanuelle Bourrat,Manuelle Viguier,Yamina Hamel,Hervé Bachelez,Asma Smahi +19 more
TL;DR: Null mutations were associated with severe clinical phenotypes, whereas hypomorphic mutations were identified in both localized (palmoplantar pustular psoriasis, acrodermatitis continua of Hallopeau) and generalized variants.
Journal ArticleDOI
Identification of Malassezia species from Tunisian patients with pityriasis versicolor and normal subjects
S. Ben Salah,Fattouma Makni,Slaheddine Marrakchi,Hayet Sellami,Fatma Cheikhrouhou,S. Bouassida,A. Zahaf,Abdelkarim Ayadi +7 more
TL;DR: It was suggested that M. globosa presents the main species implicated in the pathogenicity of PV and M. furfur as the second agent of importance.