F
Franz P.W. Radner
Researcher at University of Graz
Publications - 34
Citations - 2301
Franz P.W. Radner is an academic researcher from University of Graz. The author has contributed to research in topics: Adipose triglyceride lipase & Adipose tissue. The author has an hindex of 19, co-authored 30 publications receiving 1891 citations. Previous affiliations of Franz P.W. Radner include University Medical Center Freiburg.
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Journal ArticleDOI
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Guenter Haemmerle,Tarek Moustafa,Gerald Woelkart,Sabrina Büttner,Albrecht Schmidt,Tineke van de Weijer,Matthijs K. C. Hesselink,Doris Jaeger,Petra C. Kienesberger,Kathrin A. Zierler,Renate Schreiber,Thomas O. Eichmann,Dagmar Kolb,Petra Kotzbeck,Martina Schweiger,Manju Kumari,Sandra Eder,Gabriele Schoiswohl,Nuttaporn Wongsiriroj,Nina M. Pollak,Franz P.W. Radner,Karina Preiss-Landl,Thomas Kolbe,Thomas Rülicke,Burkert Pieske,Michael Trauner,Achim Lass,Robert Zimmermann,Gerald Hoefler,Saverio Cinti,Erin E. Kershaw,Patrick Schrauwen,Frank Madeo,Bernd Mayer,Rudolf Zechner +34 more
TL;DR: Reconstituting normal PPAR target gene expression by pharmacological treatment of Atgl-deficient mice with PPAR-α agonists completely reverses the mitochondrial defects, restores normal heart function and prevents premature death.
Journal ArticleDOI
Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance
Ulrike Taschler,Franz P.W. Radner,Christoph Heier,Renate Schreiber,Martina Schweiger,Gabriele Schoiswohl,Karina Preiss-Landl,Doris Jaeger,Birgit Reiter,Harald Koefeler,Jacek Wojciechowski,Christian Theussl,Josef M. Penninger,Achim Lass,Guenter Haemmerle,Rudolf Zechner,Robert Zimmermann +16 more
TL;DR: It is implicate that MGL deficiency impairs lipolysis and attenuates diet-induced insulin resistance, and interestingly, MGL-ko mice receiving a high fat diet exhibit significantly improved glucose tolerance and insulin sensitivity in comparison with wild-type controls despite equal weight gain.
Journal ArticleDOI
PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans.
Anais Grall,Éric Guaguère,Sandrine Planchais,Sandrine Planchais,Susanne Grond,Emmanuelle Bourrat,Ingrid Hausser,Christophe Hitte,Christophe Hitte,Matthieu Le Gallo,Matthieu Le Gallo,Céline Derbois,Gwang-Jin Kim,Laetitia Lagoutte,Laetitia Lagoutte,Frédérique Degorce-Rubiales,Franz P.W. Radner,Anne Thomas,Sébastien Küry,Sébastien Küry,Emmanuel Bensignor,Jacques Fontaine,Didier Pin,Robert Zimmermann,Rudolf Zechner,Mark Lathrop,Mark Lathrop,Francis Galibert,Francis Galibert,Catherine André,Catherine André,Judith Fischer,Judith Fischer +32 more
TL;DR: This study identifies a new gene involved in human ichthyoses and provides insights into the localization and function of this yet uncharacterized member of the PNPLA protein family.
Journal ArticleDOI
Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).
Franz P.W. Radner,Ingo E. Streith,Gabriele Schoiswohl,Martina Schweiger,Manju Kumari,Thomas O. Eichmann,Gerald N. Rechberger,Harald Koefeler,Sandra Eder,Silvia Schauer,H. Christian Theussl,Karina Preiss-Landl,Achim Lass,Robert Zimmermann,Gerald Hoefler,Rudolf Zechner,Guenter Haemmerle +16 more
TL;DR: A dual function of CGI-58 in lipid metabolism is revealed and a severe skin permeability barrier defect uncovers an essential ATGL-independent role of CGI (Cgi-58) in skin lipid metabolism.
Journal ArticleDOI
The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding
Martina Schweiger,Gabriele Schoiswohl,Achim Lass,Franz P.W. Radner,Guenter Haemmerle,Roland Malli,Wolfgang F. Graier,Irina Cornaciu,Monika Oberer,Robert Salvayre,Judith Fischer,Rudolf Zechner,Robert Zimmermann +12 more
TL;DR: The results demonstrate that the C-terminal region of ATGL is essential for proper localization of the enzyme and suppresses enzyme activity, implicating species-dependent differences in enzyme regulation.