S
Siew Eng Choon
Researcher at Monash University Malaysia Campus
Publications - 60
Citations - 2353
Siew Eng Choon is an academic researcher from Monash University Malaysia Campus. The author has contributed to research in topics: Psoriasis & Medicine. The author has an hindex of 20, co-authored 40 publications receiving 1551 citations. Previous affiliations of Siew Eng Choon include Monash University & Yahoo!.
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Journal ArticleDOI
Genetic variants associated with phenytoin-related severe cutaneous adverse reactions
Wen-Hung Chung,Wen-Hung Chung,Wan-Chun Chang,Yun-Shien Lee,Ying Ying Wu,Chih Hsun Yang,Chih Hsun Yang,Hsin Chun Ho,Hsin Chun Ho,Ming Jing Chen,Ming Jing Chen,Jing-Yi Lin,Jing-Yi Lin,Rosaline Chung-Yee Hui,Rosaline Chung-Yee Hui,Ji Chen Ho,Ji Chen Ho,Wei Ming Wu,Wei Ming Wu,Ting Jui Chen,Ting Jui Chen,Tony Wu,Tony Wu,Yih Ru Wu,Yih Ru Wu,Mo Song Hsih,Mo Song Hsih,Po Hsun Tu,Po Hsun Tu,Chen Nen Chang,Chen Nen Chang,Chien Ning Hsu,Chien Ning Hsu,Tsu Lan Wu,Tsu Lan Wu,Siew Eng Choon,Chao Kai Hsu,Der-Yuan Chen,Chin San Liu,Ching-Yuang Lin,Nahoko Kaniwa,Yoshiro Saito,Yukitoshi Takahashi,Ryosuke Nakamura,Hiroaki Azukizawa,Yongyong Shi,Tzu Hao Wang,Tzu Hao Wang,Shiow Shuh Chuang,Shiow Shuh Chuang,Shih Feng Tsai,Chee-Jen Chang,Chee-Jen Chang,Yu-Sun Chang,Shuen-Iu Hung +54 more
TL;DR: Delayed clearance of plasma phenytoin was detected in patients with severe cutaneous adverse reactions, especially CYP2C9*3 carriers, providing a functional link of the associated variants to the disease.
Journal ArticleDOI
Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis
Hervé Bachelez,Siew Eng Choon,Slaheddine Marrakchi,A. David Burden,Tsen-Fang Tsai,Akimichi Morita,Hamida Turki,David B. Hall,Michael Shear,Patrick Baum,Steven J. Padula,Christian Thoma +11 more
TL;DR: Seven patients with pustular psoriasis, three with mutations in IL36RN, were treated with a monoclonal antibody against interleukin-36 receptor and had good response to this therapy.
Journal ArticleDOI
Clinical and genetic differences between pustular psoriasis subtypes
Sophie Twelves,Alshimaa Mostafa,Alshimaa Mostafa,Nick Dand,Elias Burri,Katalin Farkas,Rosemary Wilson,Hywel L Cooper,Alan D. Irvine,Hazel H Oon,Külli Kingo,Sulev Kõks,Ulrich Mrowietz,Luis Puig,Nick J. Reynolds,Eugene Sern Ting Tan,Adrian Tanew,Kaspar Torz,Hannes Trattner,Mark C Valentine,Shyamal Wahie,Richard B. Warren,Andrew Wright,Zsuzsa Bata-Csörgő,Márta Széll,Christopher E.M. Griffiths,A. David Burden,Siew Eng Choon,Catherine H. Smith,Jonathan Barker,Alexander A. Navarini,Francesca Capon +31 more
TL;DR: In this paper, the authors sought to characterize the clinical and genetic features of pustular psoriasis through the analysis of an extended patient cohort, including 863 unrelated patients (251 with GPP, 560 with PPP, 28 with acrodermatitis continua of Hallopeau [ACH], and 24 with multiple diagnoses).
Journal ArticleDOI
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking
Niovi Setta-Kaffetzi,Michael A. Simpson,Alexander A. Navarini,Varsha M. Patel,Hui-Chun Lu,Michael H. Allen,Michael Duckworth,Hervé Bachelez,A. David Burden,Siew Eng Choon,Christopher E.M. Griffiths,Brian Kirby,Antonios G.A. Kolios,Marieke M B Seyger,Christa Prins,Asma Smahi,Richard C. Trembath,Richard C. Trembath,Franca Fraternali,Catherine H. Smith,Jonathan Barker,Francesca Capon +21 more
TL;DR: It is found that AP1S3 silencing disrupted the endosomal translocation of the innate pattern-recognition receptor TLR-3 (Toll-like receptor 3) and resulted in a marked inhibition of downstream signaling.
Journal ArticleDOI
Association of Pediatric Psoriasis Severity With Excess and Central Adiposity: An International Cross-Sectional Study
Amy S. Paller,Katherine M. Mercy,Mary J. Kwasny,Siew Eng Choon,Kelly M. Cordoro,Giampiero Girolomoni,Alan Menter,Wynnis L. Tom,Anne Marie Mahoney,A.M. Oostveen,Marieke M B Seyger +10 more
TL;DR: In this article, the authors investigated the relationship of excess and central adiposity with pediatric psoriasis severity and found that the increased metabolic risks associated with overweight and obesity warrant early monitoring and lifestyle modification.