S
Smit Kour
Researcher at Eppley Institute for Research in Cancer and Allied Diseases
Publications - 18
Citations - 448
Smit Kour is an academic researcher from Eppley Institute for Research in Cancer and Allied Diseases. The author has contributed to research in topics: Cyclin-dependent kinase & Kinase. The author has an hindex of 9, co-authored 15 publications receiving 333 citations. Previous affiliations of Smit Kour include Academy of Scientific and Innovative Research & University of Jammu.
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Journal ArticleDOI
Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)
Caroline M. Robb,Jacob I. Contreras,Smit Kour,Margaret A. Taylor,Mohammad Abid,Yogesh A. Sonawane,Muhammad Zahid,Daryl J. Murry,Amarnath Natarajan,Amarnath Natarajan,Sandeep Rana +10 more
TL;DR: This work reports the development of a heterobifunctional small molecule proteolysis targeting chimera (PROTAC) capable of cereblon (CRBN) mediated proteasomal degradation of CDK9 in HCT116 cells, the first example of a PROTAC that selectively degradesCDK9.
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Selective degradation of CDK6 by a palbociclib based PROTAC.
Sandeep Rana,Mourad Bendjennat,Smit Kour,Hannah M. King,Smitha Kizhake,Muhammad Zahid,Amarnath Natarajan +6 more
TL;DR: A palbociclib based PROTAC is reported that selectively degrades CDK6 while sparing the homolog CDK4 and used competition studies to characterize the binding and mechanism ofCDK6 degradation.
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Synthesis, characterization and mechanistic-insight into the anti-proliferative potential of PLGA-gemcitabine conjugate.
Vaibhav Khare,Smit Kour,Noor Alam,Ravindra Dubey,Ankit Saneja,Mytre Koul,Ajai Prakash Gupta,Deepika Singh,Shashank K. Singh,Shashank K. Singh,Ajit Kumar Saxena,Prem N. Gupta,Prem N. Gupta +12 more
TL;DR: The found that the prepared conjugate was not dependent on nucleoside transporter for entering into the cells and this, in turn, reflecting potential implication of this conjugates in the therapy of transporter- deficient resistance cancer.
Journal ArticleDOI
Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines.
Baljinder Singh,Santosh Kumar Guru,Smit Kour,Smit Kour,Shreyans K. Jain,Shreyans K. Jain,Rajni Sharma,Rajni Sharma,Parduman R. Sharma,Shashank K. Singh,Shashank K. Singh,Shashi Bhushan,Shashi Bhushan,Sandip B. Bharate,Sandip B. Bharate,Ram A. Vishwakarma,Ram A. Vishwakarma +16 more
TL;DR: An efficient synthesis of thiazolo[5,4-d]pyrimidines using recyclable KF/alumina catalyst is reported, which shows induction of apoptosis in A549 cells at 10 μM and cleavage of PARP-1 and procaspase-3 inhibition which confirms their apoptosis-inducing activity.
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Development and evaluation of paclitaxel loaded PLGA:poloxamer blend nanoparticles for cancer chemotherapy
Prem N. Gupta,Sharad Jain,Chetan Nehate,Noor Alam,Vaibhav Khare,Ravindra Dhar Dubey,Ankit Saneja,Smit Kour,Shashank K. Singh +8 more
TL;DR: The results indicated that the developed polymeric formulation is a novel and potential alternative for the paclitaxel delivery.