S
Sofia Lobato-Gil
Researcher at University of Montpellier
Publications - 4
Citations - 129
Sofia Lobato-Gil is an academic researcher from University of Montpellier. The author has contributed to research in topics: Proteasome & NEDD8. The author has an hindex of 4, co-authored 4 publications receiving 84 citations. Previous affiliations of Sofia Lobato-Gil include Centre national de la recherche scientifique.
Papers
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Journal ArticleDOI
NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
Chantal Maghames,Sofia Lobato-Gil,Aurélien Perrin,Helene Trauchessec,Manuel S. Rodriguez,Serge Urbach,Philippe Marin,Dimitris P. Xirodimas +7 more
TL;DR: The authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregation and protecting the ubiquitin proteasome system.
Journal ArticleDOI
Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
Sofia Lobato-Gil,Jan B. Heidelberger,Chantal Maghames,Aymeric P. Bailly,Lorene Brunello,Manuel S. Rodriguez,Petra Beli,Dimitris P. Xirodimas +7 more
TL;DR: In this article, the authors used anti-di-glycine (anti-diGly) antibodies to identify 1,101 unique NEDD8 sites in 620 proteins.
Journal ArticleDOI
Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity
Valérie Lang,Chiara Pallara,Amaia Zabala,Sofia Lobato-Gil,Fernando Lopitz-Otsoa,Rosa Farràs,Roland Hjerpe,Mónica Torres-Ramos,Lorea Zabaleta,Christine Blattner,Ronald T. Hay,Rosa Barrio,Arkaitz Carracedo,Arkaitz Carracedo,Juan Fernández-Recio,Manuel S. Rodriguez,Fabienne Aillet +16 more
TL;DR: P53 OD mutants interfere with the capacity of WT p53 tetramers to be properly ubiquitylated and result in changes of p53‐dependent protein expression patterns, including the pro‐apoptotic proteins Bax and PUMA under basal and adriamycin‐induced conditions.
Book ChapterDOI
The Ubiquitin-Proteasome System (UPS) as a Cancer Drug Target: Emerging Mechanisms and Therapeutics
TL;DR: This chapter updates some of the most successful efforts to develop and characterize inhibitors of the UPS which tackle mechanisms involved in cancer.