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Domenica Caponio
Researcher at Akershus University Hospital
Publications - 8
Citations - 1193
Domenica Caponio is an academic researcher from Akershus University Hospital. The author has contributed to research in topics: Mitophagy & Werner syndrome. The author has an hindex of 3, co-authored 5 publications receiving 540 citations. Previous affiliations of Domenica Caponio include University of Foggia & University of Oslo.
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Journal ArticleDOI
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
Evandro Fei Fang,Yujun Hou,Konstantinos Palikaras,Bryan A. Adriaanse,Jesse S. Kerr,Beimeng Yang,Sofie Lautrup,Mahdi Hasan-Olive,Domenica Caponio,Xiuli Dan,P Rocktäschel,Deborah L. Croteau,Mansour Akbari,Nigel H. Greig,Tormod Fladby,Hilde Nilsen,M Z Cader,Mark P. Mattson,Nektarios Tavernarakis,Nektarios Tavernarakis,Vilhelm A. Bohr,Vilhelm A. Bohr +21 more
TL;DR: Evidence that mitophagy is impaired in the hippocampus of AD patients, in induced pluripotent stem cell-derived human AD neurons, and in animal AD models is provided, suggesting that impaired removal of defective mitochondria is a pivotal event in AD pathogenesis and thatMitophagy represents a potential therapeutic intervention.
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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.
Evandro Fei Fang,Yujun Hou,Sofie Lautrup,Martin Borch Jensen,Beimeng Yang,Tanima SenGupta,Domenica Caponio,Rojyar Khezri,Tyler G Demarest,Yahyah Aman,David M. Figueroa,Marya Morevati,Marya Morevati,Ho-Joon Lee,Hisaya Kato,Henok Kassahun,Henok Kassahun,Jong Hyuk Lee,Deborah Filippelli,Mustafa Nazir Okur,Aswin Mangerich,Deborah L. Croteau,Yoshiro Maezawa,Costas A. Lyssiotis,Tao Jun,Koutaro Yokote,Tor Erik Rusten,Tor Erik Rusten,Mark P. Mattson,Heinrich Jasper,Hilde Nilsen,Vilhelm A. Bohr,Vilhelm A. Bohr +32 more
TL;DR: The authors showed that NAD+ repletion restores NAD+ metabolic profiles and improves mitochondrial quality through DCT-1 and ULK-1-dependent mitophagy in Werner syndrome.
Journal ArticleDOI
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
Chenglong Xie,Xuxu Zhuang,Zhangming Niu,Rui-Ting Ai,Sofie Lautrup,Shuangjia Zheng,Yinghui Jiang,Ruiyu Han,Tanima Sen Gupta,Shuqin Cao,Maria Jose Lagartos-Donate,Cui-Zan Cai,Liwei Xie,Domenica Caponio,Wen-Wen Wang,Tomas Schmauck-Medina,Jianying Zhang,He-ling Wang,Guofeng Lou,Xianglu Xiao,Wenhua Zhang,Konstantinos Palikaras,Guang Yang,Kim A. Caldwell,Guy A. Caldwell,Hanyuan Shen,Hilde Nilsen,Jiahua Lu,Evandro Fei Fang +28 more
TL;DR: In this paper , the authors report the combined use of unsupervised machine learning (involving vector representations of molecular structures, pharmacophore fingerprinting and conformer fingerprinting) and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.
Journal ArticleDOI
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
Chenglong Xie,Xuxu Zhuang,Zhangming Niu,Ruixue Ai,Sofie Lautrup,Shuangjia Zheng,Yinghui Jiang,Ruiyu Han,Tanima Sen Gupta,Shuqin Cao,Maria Jose Lagartos-Donate,Cui-Zan Cai,Liwei Xie,Domenica Caponio,Wen-Wen Wang,Tomas Schmauck-Medina,Jianying Zhang,He-ling Wang,Guofeng Lou,Xianglu Xiao,Wenhua Zhang,Konstantinos Palikaras,Guang Yang,Kim A. Caldwell,Guy A. Caldwell,Han-Ming Shen,Hilde Nilsen,Jia-Hong Lu,Evandro Fei Fang +28 more
TL;DR: In this article , the authors report the combined use of unsupervised machine learning (involving vector representations of molecular structures, pharmacophore fingerprinting and conformer fingerprinting) and a cross-species approach for the screening and experimental validation of new mitophagy-inducing compounds.
Journal ArticleDOI
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases
Sofie Lautrup,Sofie Lautrup,Domenica Caponio,Domenica Caponio,Domenica Caponio,Hoi-Hung Cheung,Claudia Piccoli,Tinna Stevnsner,Wai-Yee Chan,Evandro Fei Fang,Evandro Fei Fang +10 more
TL;DR: The latest progress of the molecular understandings of WRN protein is summarized, the advantages of using different WS model systems, including Caenorhabditis elegans, Drosophila melanogaster and induced pluripotent stem cell (iPSC) systems are highlighted and drug development for WS patients is highlighted.