K
Katie M. O'Brien
Researcher at Washington University in St. Louis
Publications - 5
Citations - 576
Katie M. O'Brien is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Disease & Asymptomatic. The author has an hindex of 3, co-authored 3 publications receiving 530 citations.
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Journal ArticleDOI
The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1
Bimmi Shrestha,James D. Brien,Soila Sukupolvi-Petty,S. Kyle Austin,Melissa A. Edeling,Taekyung Kim,Katie M. O'Brien,Christopher A. Nelson,Syd Johnson,Daved H. Fremont,Michael S. Diamond +10 more
TL;DR: A complex structural epitope on DIII of DENV-1 that can be recognized by protective antibodies with therapeutic potential is defined and sequence variation in DIII alone failed to explain disparities in neutralizing potential of MAbs among different genotypes.
Journal ArticleDOI
Tregs control the development of symptomatic West Nile virus infection in humans and mice
Marion C. Lanteri,Katie M. O'Brien,Whitney E. Purtha,Mark J. Cameron,Jennifer M. Lund,Rachel E. Owen,John W. Heitman,Brian Custer,Dale F. Hirschkorn,Leslie H. Tobler,Nancy Kiely,Harry E. Prince,Lishomwa C. Ndhlovu,Douglas F. Nixon,Hany Kamel,David J. Kelvin,Michael P. Busch,Alexander Y. Rudensky,Michael S. Diamond,Philip J. Norris +19 more
TL;DR: It is suggested that higher levels of peripheral Tregs after infection protect against severe WNV disease in immunocompetent animals and humans.
Journal ArticleDOI
Genotype-Specific Neutralization and Protection by Antibodies against Dengue Virus Type 3
James D. Brien,S. Kyle Austin,Soila Sukupolvi-Petty,Katie M. O'Brien,Syd Johnson,Daved H. Fremont,Michael S. Diamond +6 more
TL;DR: While several MAbs functioned prophylactically to prevent DENV-3-induced lethality in a stringent intracranial-challenge model of mice, only three MAbs exhibited therapeutic activity against a homologous strain when administered 2 days after infection.
Journal ArticleDOI
Effectiveness of rapid antigen testing for screening of asymptomatic individuals to limit the transmission of SARS‐CoV‐2: A rapid review
Kieran A. Walsh,Natasha Broderick,Susan Ahern,Christopher G. Fawsitt,Katie M. O'Brien,Marie Carrigan,Patricia Harrington,Michelle O'Neill,Susan M Smith,Susan Spillane,Conor Teljeur,Máirín Ryan +11 more
TL;DR: There is uncertainty regarding the effectiveness of rapid antigen testing for the screening of asymptomatic individuals to limit the transmission of SARS‐CoV‐2, and more real‐world research evidence in relevant settings is required to inform public policy on the widespread use of RADTs.
Journal ArticleDOI
Views on COVID-19 vaccination of young children in Ireland, results from a cross-sectional survey of parents
Louise Marron,Annamária Ferenczi,Katie M. O'Brien,Suzanne Cotter,Lucy Jessop,Yvonne Morrissey,Chantal Migone +6 more
TL;DR: In this paper , a cross-sectional national survey of parental attitudes towards childhood vaccination in Ireland was conducted between June and August 2021, a total of 855 parents were surveyed to determine their attitudes towards COVID-19 vaccines for their children.