M
Melissa A. Edeling
Researcher at Washington University in St. Louis
Publications - 27
Citations - 2623
Melissa A. Edeling is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Virus & Epitope. The author has an hindex of 20, co-authored 25 publications receiving 2336 citations. Previous affiliations of Melissa A. Edeling include University of Washington & University of Queensland.
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Journal ArticleDOI
Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus
Pankaj Pal,Kimberly A. Dowd,James D. Brien,Melissa A. Edeling,Sergey Gorlatov,Syd Johnson,Iris Lee,Wataru Akahata,Gary J. Nabel,Mareike K. S. Richter,Jolanda M. Smit,Daved H. Fremont,Theodore C. Pierson,Mark T. Heise,Michael S. Diamond +14 more
TL;DR: Administration of a single dose of a combination of two neutralizing MAbs limited the development of resistance and protected immunocompromised mice against disease when given 24 to 36 hours before CHIKV-induced death.
Journal ArticleDOI
Life of a clathrin coat: insights from clathrin and AP structures.
TL;DR: This work has shown that the determination of structures of clathrin assemblies by electron microscopy, of domains ofclathrin and of its adaptors has improved the understanding of the molecular mechanisms ofClathrin-coated-vesicle assembly and disassembly.
Journal ArticleDOI
The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1
Bimmi Shrestha,James D. Brien,Soila Sukupolvi-Petty,S. Kyle Austin,Melissa A. Edeling,Taekyung Kim,Katie M. O'Brien,Christopher A. Nelson,Syd Johnson,Daved H. Fremont,Michael S. Diamond +10 more
TL;DR: A complex structural epitope on DIII of DENV-1 that can be recognized by protective antibodies with therapeutic potential is defined and sequence variation in DIII alone failed to explain disparities in neutralizing potential of MAbs among different genotypes.
Journal ArticleDOI
Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.
Katherine Bowers,Siân C. Piper,Melissa A. Edeling,Sally R. Gray,David J. Owen,Paul J. Lehner,J. Paul Luzio +6 more
TL;DR: The data suggest that mammalian ESCRTII may be redundant, cargo-specific, or not required for protein sorting at the multivesicular body.
Journal ArticleDOI
Molecular Switches Involving the AP-2 β2 Appendage Regulate Endocytic Cargo Selection and Clathrin Coat Assembly
Melissa A. Edeling,Sanjay K. Mishra,Peter A. Keyel,Amie L. Steinhauser,Brett M. Collins,Robyn Roth,John E. Heuser,David J. Owen,Linton M. Traub +8 more
TL;DR: It is shown that these two CLASPs bind selectively to the AP-2 beta2 appendage platform via an alpha-helical [DE](n)X(1-2)FXX[FL]XXXR motif, and that this motif also occurs and is functional in the epsins.