S
Soo-Kyung Bae
Researcher at Pusan National University
Publications - 73
Citations - 4496
Soo-Kyung Bae is an academic researcher from Pusan National University. The author has contributed to research in topics: Angiogenesis & Downregulation and upregulation. The author has an hindex of 30, co-authored 68 publications receiving 4160 citations. Previous affiliations of Soo-Kyung Bae include Kyoto University & Laboratory of Molecular Biology.
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Journal ArticleDOI
Notch signalling regulates stem cell numbers in vitro and in vivo.
Andreas Androutsellis-Theotokis,Ronen R. Leker,Frank Soldner,Daniel J. Hoeppner,Rea Ravin,Steve W. Poser,Maria Adele Rueger,Soo-Kyung Bae,Raja Kittappa,Ronald D.G. McKay +9 more
TL;DR: Notch receptor activation induces the expression of the specific target genes hairy and enhancer of split 3 and Sonic hedgehog through rapid activation of cytoplasmic signals, including the serine/threonine kinase Akt, the transcription factor STAT3 and mammalian target of rapamycin, and thereby promotes the survival of neural stem cells.
Journal ArticleDOI
Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development.
You Mie Lee,Chul-Ho Jeong,Sun-Young Koo,Myung Jin Son,Hyun Seok Song,Soo-Kyung Bae,Soo-Kyung Bae,James A. Raleigh,Hae Young Chung,Mi-Ae Yoo,Kyu-Won Kim +10 more
TL;DR: The data clearly show that hypoxia marker immunoreactivity was highly detected in developing neural tubes, heart, and intersomitic mesenchyme at an early stage of organogenesis, suggesting that Hypoxia may exist in the early stages of embryo development.
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Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-κB activation in endothelial cells
Su Ryun Kim,Yun Hee Bae,Soo-Kyung Bae,Kyu Sil Choi,Kwon Ha Yoon,Tae Hyeon Koo,Hye Ock Jang,Il Yun,Kyu-Won Kim,Young Guen Kwon,Mi-Ae Yoo,Moon-Kyoung Bae +11 more
TL;DR: It is demonstrated that visfatin is a vascular inflammatory molecule that increases expression of the inflammatory CAMs, ICAM-1 and VCAM- 1, through ROS-dependent NF-kappaB activation in endothelial cells.
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The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation
TL;DR: Mutation analysis revealed that Hes1- and Hes6-specific functions are, at least in part, interchangeable by alteration of the loop region, suggesting that the loop is not simply a nonfunctional spacer but plays an important role in the specific functions.
Journal Article
Insulin-like Growth Factor II Induced by Hypoxia May Contribute to Angiogenesis of Human Hepatocellular Carcinoma
TL;DR: It is demonstrated that IGF-II substantially increases vascular endothelial growth factor (VEGF) mRNA and protein levels in a time-dependent manner in human hepatoma cells, suggesting that hypoxia may be a strong stimulus for the induction of IGF- II expression in the process of hepatocarcinogenesis.