S
Sookhee Chun
Researcher at City of Hope National Medical Center
Publications - 2
Citations - 181
Sookhee Chun is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Leukemia & Stem cell. The author has an hindex of 1, co-authored 2 publications receiving 148 citations.
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Journal ArticleDOI
SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells
Ling Li,Tereza Osdal,YinWei Ho,Sookhee Chun,Tinisha McDonald,Puneet Agarwal,Allen Lin,Su Chu,Jing Qi,Liang Li,Yao-Te Hsieh,Cedric Dos Santos,Hongfeng Yuan,Trung-Quang Ha,Mihaela Popa,Randi Hovland,Øystein Bruserud,Øystein Bruserud,Bjørn Tore Gjertsen,Bjørn Tore Gjertsen,Ya-Huei Kuo,WenYong Chen,Sonia Lain,Emmet McCormack,Emmet McCormack,Ravi Bhatia +25 more
TL;DR: It is shown that the NAD-dependent SIRT1 deacetylase is selectively overexpressed in primary human FLT3-ITD AML LSCs and contributes to their maintenance.
Journal ArticleDOI
Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI Treatment
Ling Li,Tereza Osdal,YinWei Ho,Tinisha McDonald,Sookhee Chun,Su Chu,Allen Lin,Cedric Dos Santos,Mihaela Popa,Bjørn Tore Gjertsen,WenYong Chen,Sonia Lain,Emmet McCormack,Ravi Bhatia +13 more
TL;DR: It is shown that treatment of FLT3-ITD+ AML CD34+ cells with the TKI AC220 did not significantly reduce SIRT1 levels, increase p53 acetylation, or increase p 53 target gene expression, suggesting that kinase independent mechanisms maintain SIRT 1 expression and activity in TKI-treated cells.