Ling Li

TL;DR: It is shown that the NAD(+)-dependent deacetylase SIRT1 is overexpressed in human CML LSC and Activation of p53 via Sirt1 inhibition represents a potential approach to target C ML LSC.

TL;DR: Shikonin, a naturally occurring naphthoquinone, induced a cell death in MCF-7 and HEK293 distinct from apoptosis and characterized with (a) a morphology of necrotic cell death, (b) loss of plasma membrane integrity, loss of mitochondrial membrane potentials, activation of autophagy, but not a contributing factor; (e) elevation of reactive oxygen species with no critical roles contributing to cell death; and (f) the cell death was prevented by a small molecule, necrostatin-1, that specifically

TL;DR: It is shown that genetic depletion and pharmacological inhibition of FTO dramatically attenuate leukemia stem/initiating cell self-renewal and reprogram immune response by suppressing expression of immune checkpoint genes, especially LILRB4.

TL;DR: Current advances in understanding normal stem cell quiescence, their significance for CSC quiescent and drug resistance, and the potential clinical applications are reviewed.

TL;DR: It is shown that the NAD-dependent SIRT1 deacetylase is selectively overexpressed in primary human FLT3-ITD AML LSCs and contributes to their maintenance.