Spasenija Savic Prince

TL;DR: The characterization of a distinct state of tumor-reactive, PD-1-bright lymphocytes in human cancer, which only partially resembles that seen in chronic infection, provides potential avenues for therapeutic intervention.

TL;DR: A comprehensive characterization of the diversity and expression patterns of inhibitory receptors on tumor-infiltrating T cells from patients with non–small cell lung cancer is provided to provide a framework for future personalized T-cell–based therapies aiming at restoration of tumor- infiltration lymphocyte effector functions.

TL;DR: For patients with resectable stage IIIA(N2) non-small-cell lung cancer, neoadjuvant chemotherapy with cisplatin and docetaxel followed by surgery resulted in a 1-year event-free survival as discussed by the authors.

TL;DR: This study supports TMB evaluation through targeted NGS in NSCLC patient samples as a tool to predict response to ICI therapy and offers recommendations for a reliable and cost‐effective assessment of TMB in a routine diagnostic setting.

TL;DR: It is concluded that cytology specimens are in principal suitable for predictive ICC, but proper optimization and rigorous quality control for high‐quality staining are essential, particularly for non‐CB preparations.