Spencer T. Chen

TL;DR: Most convalescent plasma samples obtained from individuals who recover from COVID-19 do not contain high levels of neutralizing activity, and rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.

TL;DR: It is established that sequential immunization with specifically designed immunogens can induce high levels of somatic mutation and shepherd antibody maturation to produce bNAbs from their inferred germline precursors.

TL;DR: It is found that contemporaneously developing memory and GC B cells differ in their affinity for antigen throughout the immune response, and the polyclonal memory B cell compartment is composed of B cells that were activated during the immune responded but whose antigen binding affinity failed to support further clonal expansion in the GC.

TL;DR: Rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.

TL;DR: In this article, the origins and properties of memory B cells subsets in mice with an intact immune system were explored. But the results were limited to the case of mice with a single memory cell.