S
Srikanth Talluri
Researcher at Harvard University
Publications - 54
Citations - 707
Srikanth Talluri is an academic researcher from Harvard University. The author has contributed to research in topics: Genome instability & Biology. The author has an hindex of 11, co-authored 38 publications receiving 454 citations. Previous affiliations of Srikanth Talluri include VA Boston Healthcare System & Sri Venkateswara Institute of Medical Sciences.
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HOTAIR LncRNA: A novel oncogenic propellant in human cancer.
TL;DR: A more comprehensive understanding of this unique lncRNA is critical to elucidating the pro-oncogenic function of HOTAIR its potential application in diagnosis, prognosis and treatment.
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Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy.
Courtney H. Coschi,Charles A. Ishak,David Gallo,Aren E. Marshall,Srikanth Talluri,Jianxin Wang,Matthew J. Cecchini,Alison L. Martens,Vanessa Percy,Ian Welch,Paul C. Boutros,Grant W. Brown,Frederick A. Dick +12 more
TL;DR: It is demonstrated that instability can be caused by loss of a single allele of the retinoblastoma gene that prevents proper replication and condensation of pericentromeric chromosomal regions, leading to elevated levels of aneuploidy in cancer.
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Regulation of transcription and chromatin structure by pRB: Here, there and everywhere
TL;DR: Retinoblastoma function is discussed through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains, and its role in controlling chromatin structure is expanding and bringing it into new regulatory paradigms.
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A G1 Checkpoint Mediated by the Retinoblastoma Protein That Is Dispensable in Terminal Differentiation but Essential for Senescence
Srikanth Talluri,Christian Isaac,Mohammad Ahmad,Shauna A. Henley,Sarah M. Francis,Alison L. Martens,Rod Bremner,Frederick A. Dick +7 more
TL;DR: This work demonstrates that a subtle mutation in pRB that cripples its ability to interact with chromatin regulators impairs heterochromatinization and repression of E2F-responsive promoters during senescence, and reveals that pRB recruits Chromatin regulators primarily to engage a stress-responsive G1 arrest program.
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Bortezomib Induces Anti-Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation.
Annamaria Gulla,Eugenio Morelli,Mehmet Kemal Samur,Cirino Botta,Teru Hideshima,Giada Bianchi,Mariateresa Fulciniti,Stefano Malvestiti,Rao Prabhala,Rao Prabhala,Srikanth Talluri,Srikanth Talluri,Kenneth Wen,Yu-Tzu Tai,Paul G. Richardson,Dharminder Chauhan,Tomasz Sewastianik,Ruben D. Carrasco,Ruben D. Carrasco,Nikhil C. Munshi,Nikhil C. Munshi,Kenneth C. Anderson +21 more
TL;DR: It is shown that bortezomib triggers immunogenic cell death (ICD), characterized by exposure of calreticulin on dying multiple myeloma cells, phagocytosis of tumor cells by dendritic cells, and induction of multipleMyeloma-specific immunity.