Journal ArticleDOI
HOTAIR LncRNA: A novel oncogenic propellant in human cancer.
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TLDR
A more comprehensive understanding of this unique lncRNA is critical to elucidating the pro-oncogenic function of HOTAIR its potential application in diagnosis, prognosis and treatment.About:
This article is published in Clinica Chimica Acta.The article was published on 2020-04-01. It has received 91 citations till now. The article focuses on the topics: HOTAIR & microRNA.read more
Citations
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NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer.
Ali R. Özeş,David F.B. Miller,Osman Nidai Ozes,Fang Fang,Yunlong Liu,Daniela Matei,Tim H M Huang,Kenneth P. Nephew +7 more
TL;DR: In this paper, the role of HOTAIR during DNA damage induced by platinum was investigated, and it was shown that HotaIR expression results in sustained activation of DNA damage response (DDR) after platinum treatment.
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The Role of non-coding RNAs in colorectal cancer, with a focus on its autophagy.
Li Chen,Man He,Meng Zhang,Qiang Sun,Sha Zeng,Hui Zhao,Han Yang,Maolun Liu,Shan Ren,Xianli Meng,Haibo Xu +10 more
TL;DR: In this paper, the regulatory role of non-coding RNAs (ncRNAs) in CRC-related autophagy has been investigated, with the aim of shedding light on the complex pathological mechanisms, involving ncRNAs and autophagia, responsible for CRC tumorigenesis and development.
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Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2.
Xiaohong Xiang,Yunong Fu,Kun Zhao,Runchen Miao,Xing Zhang,Xiaohua Ma,Chang Liu,Nu Zhang,Kai Qu +8 more
TL;DR: In this article, the role of PINT87aa in hepatocellular carcinoma (HCC) cellular senescence was investigated by monitoring cell proliferation and performed flow cytometry, β-galactosidase staining, JC-1 staining indicative of mitochondrial membrane potential, and the ratio of the overlapping area of light chain 3 beta (LC3B) and mitochondrial probes.
Journal ArticleDOI
Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma.
TL;DR: Recent advances concerning the biological function of lncRNAs as ceRNAs in HCC are emphasized with the aim of elucidating the molecular mechanism underlying these HCC-related RNA molecules and providing novel insights into the diagnosis and treatment of HCC.
Journal ArticleDOI
Exosomal-long non-coding RNAs journey in colorectal cancer: Evil and goodness faces of key players
TL;DR: In this article , the authors collected and addressed recent studies concerned with exosomes and their cargos' implications for colorectal cancer diagnosis and/or hopefully, treatment.
References
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Journal ArticleDOI
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray,Jacques Ferlay,Isabelle Soerjomataram,Rebecca L. Siegel,Lindsey A. Torre,Ahmedin Jemal +5 more
TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
Journal ArticleDOI
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
TL;DR: The GLOBOCAN series of the International Agency for Research on Cancer (IARC) as mentioned in this paper provides estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012.
Journal ArticleDOI
Cancer statistics, 2019.
TL;DR: The overall cancer death rate dropped continuously from 1991 to 2016 by a total of 27%, translating into approximately 2,629,200 fewer cancer deaths than would have been expected if death rates had remained at their peak.
Journal ArticleDOI
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Sendurai A. Mani,Wenjun Guo,Mai Jing Liao,Elinor Ng Eaton,Ayyakkannu Ayyanan,Alicia Y. Zhou,Mary W. Brooks,Ferenc Reinhard,Cheng Cheng Zhang,Michail Shipitsin,Lauren L. Campbell,Kornelia Polyak,Cathrin Brisken,Jing Yang,Robert A. Weinberg +14 more
TL;DR: It is reported that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers, and it is shown that those cells have an increased ability to form mammospheres, a property associated with mammARY epithelial stem cells.
Journal ArticleDOI
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta,Nilay Shah,Kevin C. Wang,Jeewon Kim,Hugo M. Horlings,David J. Wong,Miao-Chih Tsai,Tiffany Hung,Pedram Argani,John L. Rinn,Yulei Wang,Pius Brzoska,Benjamin Kong,Rui-Chun Li,Robert B. West,Marc J. van de Vijver,Saraswati Sukumar,Howard Y. Chang +17 more
TL;DR: It is shown that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression, indicating that l incRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.