Stafford L. Lightman

TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

TL;DR: Oxytocin exerts a central anxiolytic-like effect on both endocrine and behavioral systems and could play a role in moderating behavioral and physiological responses to stress.

TL;DR: Elderly carers of spouses with dementia have increased activation of the hypothalamic-pituitary-adrenal axis and a poor antibody response to influenza vaccine, and carers may be more vulnerable to infectious disease than the population of a similar age.

TL;DR: A model in which the basal occupancy of transcription factors acts to prime chromatin and direct inducible transcription factors to select regions in the genome is proposed, and the maintenance of baseline chromatin accessibility facilitates GR recruitment and is dependent on AP1 binding.

TL;DR: The molecular mechanisms involved in regulating the metabolism of tryptophan are discussed, the medical implications associated with dysregulation of both serotonergic and kynurenine pathways of tryPTophan metabolism are considered and the pathophysiology of conditions such as acquired immunodeficiency syndrome, Huntington's disease and Alzheimer's disease is considered.