抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

This paper describes the ATLAS experiment as installed in i ts experimental cavern at point 1 at CERN. It also presents a brief overview of the expec ted performance of the detector.

http://absimage.aps.org/image/SES08/MWS_SES08-2008-020010.pdf

The ATLAS Experiment at the CERN Large Hadron Collider

There is a special reason for reviewing this book at this time: it is the 50th edition of a compendium that is known and used frequently in most chemical and physical laboratories in many parts of the world. Surely, a publication that has been published for 56 years, withstanding the vagaries of science in this century, must have had something to offer. There is another reason: while the book is a standard fixture in most chemical and physical laboratories, including those in medical centers, it is not as frequently seen in the laboratories of physician's offices (those either in solo or group practice). I believe that the Handbook can be useful in those laboratories. One of the reasons, among others, is that the various basic items of information it offers may be helpful in new tests, either physical or chemical, which are continuously being published. The basic information may relate

Handbook of Chemistry and Physics

We report new insights into the electrochemical reduction of CO2 on a metallic copper surface, enabled by the development of an experimental methodology with unprecedented sensitivity for the identification and quantification of CO2 electroreduction products. This involves a custom electrochemical cell designed to maximize product concentrations coupled to gas chromatography and nuclear magnetic resonance for the identification and quantification of gas and liquid products, respectively. We studied copper across a range of potentials and observed a total of 16 different CO2 reduction products, five of which are reported here for the first time, thus providing the most complete view of the reaction chemistry reported to date. Taking into account the chemical identities of the wide range of C1–C3 products generated and the potential-dependence of their turnover frequencies, mechanistic information is deduced. We discuss a scheme for the formation of multicarbon products involving enol-like surface intermediates as a possible pathway, accounting for the observed selectivity for eleven distinct C2+ oxygenated products including aldehydes, ketones, alcohols, and carboxylic acids.

New insights into the electrochemical reduction of carbon dioxide on metallic copper surfaces

The electrocatalytic hydrogen-evolution reaction (HER), as the main step of water splitting and the cornerstone of exploring the mechanism of other multi-electron transfer electrochemical processes, is the subject of extensive studies. A large number of high-performance electrocatalysts have been developed for HER accompanied by recent significant advances in exploring its electrochemical nature. Herein we present a critical appraisal of both theoretical and experimental studies of HER electrocatalysts with special emphasis on the electronic structure, surface (electro)chemistry, and molecular design. It addresses the importance of correlating theoretical calculations and electrochemical measurements toward better understanding of HER electrocatalysis at the atomic level. Fundamental concepts in the computational quantum chemistry and its relation to experimental electrochemistry are also presented along with some featured examples.

Advancing the Electrochemistry of the Hydrogen-Evolution Reaction through Combining Experiment and Theory

On the basis of a comparison of the oxidation activity of a series of similar alcohols with varying pKa on gold electrodes in alkaline solution, we find that the first deprotonation is base catalyz...

Electrocatalytic Oxidation of Alcohols on Gold in Alkaline Media: Base or Gold Catalysis?

Metal nanoparticles (NPs) find widespread application as a result of their unique physical and chemical properties. NPs have generated considerable interest in catalysis and electrocatalysis, where they provide a high surface area to mass ratio and can be tailored to promote particular reaction pathways. The activity of NPs can be analyzed especially well using electrochemistry, which probes interfacial chemistry directly. In this Review, we discuss key issues related to the electrochemistry of NPs. We highlight model studies that demonstrate exceptional control over the NP shape and size, or mass-transport conditions, which can provide key insights into the behavior of ensembles of NPs. Particular focus is on the challenge of ultimately measuring reactions at individual NPs, and relating the response to their structure, which is leading to imaginative experiments that have an impact on electrochemistry in general as well as broader surface and colloid science.

Electrochemistry of nanoparticles.

Scanning electrochemical cell microscopy (SECCM) is a new pipette-based imaging technique purposely designed to allow simultaneous electrochemical, conductance, and topographical visualization of surfaces and interfaces. SECCM uses a tiny meniscus or droplet, at the end of a double-barreled (theta) pipette, for high-resolution functional imaging and nanoscale electrochemical measurements. Here we introduce this technique and provide an overview of its principles, instrumentation, and theory. We discuss the power of SECCM in resolving complex structure-activity problems and provide considerable new information on electrode processes by referring to key example systems, including graphene, graphite, carbon nanotubes, nanoparticles, and conducting diamond. The many longstanding questions that SECCM has been able to answer during its short existence demonstrate its potential to become a major technique in electrochemistry and interfacial science.

/pdf/scanning-electrochemical-cell-microscopy-a-versatile-n534e08if2.pdf

Scanning Electrochemical Cell Microscopy: A Versatile Technique for Nanoscale Electrochemistry and Functional Imaging

Effects of electrolyte pH and composition on the ethanol electro-oxidation reaction

The electrochemical oxidation of ethanol as well as its irreversible adsorption on platinum single crystal electrodes has been studied in an alkaline solution. In addition, the adsorbed species in the ethanol oxidation reaction were also studied by means of surface enhanced Raman spectroscopy (SERS) on a platinum film electrode. It was found that the oxidation of ethanol is very sensitive to the electrode surface structure: a higher concentration of low-coordination sites increases the current, lowers the overpotential required and lowers the deactivation rate. Furthermore, the terrace length also affects the amounts and the nature of the adsorbed species: on Pt (110), only COad was observed, whereas adsorbed CHx could only be found on electrode surfaces with (111) terrace sites. Based on the results here, a model for the ethanol electro-oxidation reaction in alkaline media is presented, and the differences with the same reaction in acidic media are pointed out.

Stanley C. S. Lai

Papers

Electrocatalytic Oxidation of Alcohols on Gold in Alkaline Media: Base or Gold Catalysis?

Electrochemistry of nanoparticles.

Scanning Electrochemical Cell Microscopy: A Versatile Technique for Nanoscale Electrochemistry and Functional Imaging

Effects of electrolyte pH and composition on the ethanol electro-oxidation reaction

Ethanol electro-oxidation on platinum in alkaline media.