S
Stayce E. Beck
Researcher at University of California, San Diego
Publications - 10
Citations - 451
Stayce E. Beck is an academic researcher from University of California, San Diego. The author has contributed to research in topics: SMAD & Transforming growth factor. The author has an hindex of 7, co-authored 8 publications receiving 401 citations.
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Journal ArticleDOI
Bone morphogenetic protein signaling and growth suppression in colon cancer
Stayce E. Beck,Barbara H. Jung,Antonio Fiorino,Jessica Gomez,Eunice Del Rosario,Betty L. Cabrera,Sherry C. Huang,Jimmy Y. C. Chow,John M. Carethers,John M. Carethers +9 more
TL;DR: BMP signaling is intact and growth suppressive in human colon cancer cells, and in addition to SMADs, BMP may utilize SMAD4-independent pathways for growth suppression in colon cancers.
Journal ArticleDOI
RAS/ERK modulates TGFβ-regulated PTEN expression in human pancreatic adenocarcinoma cells
Jimmy Y. C. Chow,Khai T. Quach,Betty L. Cabrera,Jennifer Cabral,Stayce E. Beck,John M. Carethers,John M. Carethers +6 more
TL;DR: Oncogenic K-RAS/ERK in pancreatic adenocarcinoma facilitates TGFbeta-induced transcriptional down-regulation of the tumor suppressor PTEN in a SMAD4-independent manner and could constitute a signaling switch mechanism from growth suppression to growth promotion in Pancic cancers.
Journal ArticleDOI
BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK
Stayce E. Beck,Barbara H. Jung,Barbara H. Jung,Eunice Del Rosario,Jessica Gomez,John M. Carethers +5 more
TL;DR: In colon cancer cells, BMP-SMAD signaling and growth suppression is facilitated by p21(WAF1) but modulated by oncogenic K-RAS to reduce the growth suppression directed by this pathway.
Journal ArticleDOI
Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin.
Barbara H. Jung,Barbara H. Jung,Stayce E. Beck,Jennifer Cabral,Eddy Chau,Betty L. Cabrera,Antonio Fiorino,E. Julieta Smith,Melanie Bocanegra,John M. Carethers +9 more
TL;DR: ACVR2-complemented MSI-H colon cancers restore activin-SMAD signaling, decrease growth, and slow their cell cycle following ligand stimulation but show increased cellular migration.
Journal ArticleDOI
BMP Suppresses PTEN Expression via RAS/ERK Signaling
Stayce E. Beck,John M. Carethers +1 more
TL;DR: Bone morphogenetic protein downregulates PTEN via RAS/ERK in a SMAD4-null environment that contributes to cell growth, and constitutes a SMad4-independent but BMP-responsive signaling pathway.