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Stefan Deneberg
Researcher at Karolinska University Hospital
Publications - 31
Citations - 1086
Stefan Deneberg is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 13, co-authored 27 publications receiving 855 citations. Previous affiliations of Stefan Deneberg include Karolinska Institutet.
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Journal ArticleDOI
Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry.
Sebastian Lehmann,A. Ravn,L. Carlsson,Petar Antunovic,Stefan Deneberg,Lars Möllgård,A. Rangert Derolf,Dick Stockelberg,Ulf Tidefelt,Anders Wahlin,Lovisa Wennström,Martin Höglund,Gunnar Juliusson +12 more
TL;DR: It is concluded that ED rates remain very high in an unselected APL population in the population-based Swedish Adult Acute Leukemia Registry, and female sex predominated among younger APL patients.
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Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia.
Stefan Deneberg,Michael Grövdal,Mohsen Karimi,Mohsen Karimi,Monika Jansson,Hareth Nahi,Andrea Corbacioglu,Verena I. Gaidzik,Konstanze Döhner,Christer Paul,Tomas J. Ekström,Eva Hellström-Lindberg,Sören Lehmann +12 more
TL;DR: It is concluded that global and gene-specific methylation patterns are independently associated with the clinical outcome in AML patients.
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Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes
Ying Qu,Andreas Lennartsson,Verena I. Gaidzik,Stefan Deneberg,Mohsen Karimi,Sofia Bengtzen,Martin Höglund,Lars Bullinger,Konstanze Döhner,Sören Lehmann +9 more
TL;DR: It is shown that, in CN-AML, the most pronounced changes in DNA methylation occur in non-CGI regions and that DNMT3A mutations confer a pattern of global hypomethylation that specifically targets HOX genes.
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Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks
Stefan Deneberg,Philippe Guardiola,Andreas Lennartsson,Ying Qu,Verena E. Gaidzik,Odile Blanchet,Mohsen Karimi,Sofia Bengtzen,Hareth Nahi,Bertil Uggla,Ulf Tidefelt,Martin Höglund,C. Paul,Karl Ekwall,Konstanze Döhner,Sören Lehmann +15 more
TL;DR: In this article, the authors investigated the effect of DNA methylation on the prognosis of acute myeloid leukemia (AML) cases and showed that high methylation levels of PcG target genes were associated with better progression-free survival (odds ratio = 0.47, P =.01) and overall survival.
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An open-label phase I dose-finding study of APR-246 in hematological malignancies.
Stefan Deneberg,Honar Cherif,Vladimir Lazarevic,P-O Andersson,M. von Euler,Gunnar Juliusson,Sören Lehmann,Sören Lehmann +7 more
TL;DR: This is an extension of the first in-man study aiming at optimizing the dose regimen to obtain better antitumor response with less toxicity of APR-246, the first compound targeting mutant p53 to enter into a clinical trial.