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Karl Ekwall

Researcher at Karolinska Institutet

Publications -  139
Citations -  10170

Karl Ekwall is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Chromatin & Heterochromatin. The author has an hindex of 48, co-authored 137 publications receiving 9272 citations. Previous affiliations of Karl Ekwall include Novum & Uppsala University.

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A promoter-level mammalian expression atlas

Alistair R. R. Forrest, +280 more
- 27 Mar 2014 - 
TL;DR: For example, the authors mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body.
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Comparative functional genomics of the fission yeasts

Nicholas Rhind, +66 more
- 20 May 2011 - 
TL;DR: Differences in gene content and regulation explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source and provide tools for investigation across the Schizosaccharomyces clade.
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Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.

TL;DR: It is proposed that the products of these genes are integral in the assembly of a heterochromatin-like structure, with distinct domains, enclosing the entire centromeric region that reduces or excludes access to transcription factors.
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Transient Inhibition of Histone Deacetylation Alters the Structural and Functional Imprint at Fission Yeast Centromeres

TL;DR: In this article, a role for histone acetylation in centromere regulation has been identified, where exposure of fission yeast cells to TSA, a specific inhibitor of histone deacetylase, interferes with repression of marker genes, causes chromosome loss, and disrupts the localization of Swi6p.
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The chromodomain protein Swi6 : a key component at fission yeast centromeres

TL;DR: It is shown that Swi6p localizes with these three chromosomal regions in the fission yeast Schizosaccharomyces pombe and is required for their proper function.