S
Stefan Joos
Researcher at German Cancer Research Center
Publications - 95
Citations - 8427
Stefan Joos is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Comparative genomic hybridization & Fluorescence in situ hybridization. The author has an hindex of 49, co-authored 95 publications receiving 8167 citations. Previous affiliations of Stefan Joos include Heidelberg University & University of Lübeck.
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Journal ArticleDOI
Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization
Stanislas du Manoir,Michael R. Speicher,Stefan Joos,Evelin Schröck,Susanne Popp,Hartmut Döhner,Gyula Kovacs,Michel Robert-Nicoud,Peter Lichter,Thomas Cremer +9 more
TL;DR: A tight correlation of fluorescence ratio values with hapten ratios is indicated, and the potential offluorescence ratio measurements for multiple color chromosome painting is identified, for chromosome identification.
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The role of Bcl-2 family members in tumorigenesis.
TL;DR: Since several Bcl-2 homologues, in addition to influencing apoptotic behaviour, also impinge on cell cycle progression, it is discussed possible implications of this additional role for the expression of B cl-2 family members in tumor cells.
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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
Stefan M. Pfister,Wibke G. Janzarik,Marc Remke,Aurélie Ernst,Wiebke Werft,Natalia Becker,Grischa Toedt,Andrea Wittmann,Christian P. Kratz,Heike Olbrich,Rezvan Ahmadi,Barbara Thieme,Stefan Joos,Bernhard Radlwimmer,Andreas E. Kulozik,Torsten Pietsch,Christel Herold-Mende,Astrid Gnekow,Guido Reifenberger,Andrey Korshunov,Wolfram Scheurlen,Heymut Omran,Peter Lichter +22 more
TL;DR: Both the stable silencing of BRAF through shRNA lentiviral transduction and pharmacological inhibition of MEK1/2, the immediate downstream phosphorylation target of BRAf, blocked the proliferation and arrested the growth of cultured tumor cells derived from low-grade gliomas and suggest inhibition of the MAPK pathway as a potential treatment.
Journal ArticleDOI
Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene
Stefan Joos,MI Otano-Joos,S Ziegler,Silke Brüderlein,S du Manoir,Martin Bentz,Peter Möller,P. Lichter +7 more
TL;DR: The characteristic pattern of chromosomal imbalances distinct from other B-cell lymphomas suggests a specific pathway of genetic changes associated with this lymphoma.
Journal ArticleDOI
Quantitative analysis of comparative genomic hybridization
Stanislas du Manoir,Evelin Schröck,Martin Bentz,Michael R. Speicher,Stefan Joos,Thomas Ried,Peter Lichter,Thomas Cremer +7 more
TL;DR: The granularity of the chromosome painting and the regional inhomogeneity of fluorescence intensities in metaphase spreads proved to be crucial parameters for quantitative evaluations of CGH experiments.