M
Martin Zörnig
Researcher at Goethe University Frankfurt
Publications - 54
Citations - 6389
Martin Zörnig is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Regulation of gene expression & Fas receptor. The author has an hindex of 31, co-authored 54 publications receiving 5810 citations. Previous affiliations of Martin Zörnig include Yonsei University & Lincoln's Inn.
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Journal ArticleDOI
The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Tony Gutschner,Monika Hämmerle,Moritz Eißmann,Jeff Hsu,Youngsoo Kim,Gene Hung,Alexey S. Revenko,Gayatri Arun,Marion Stentrup,Matthias Groß,Martin Zörnig,A. Robert MacLeod,David L. Spector,Sven Diederichs +13 more
TL;DR: A loss-of-function model unravels the active function of MALAT1 as a regulator of gene expression governing hallmarks of lung cancer metastasis with this ncRNA serving as both predictive marker and therapeutic target.
Journal ArticleDOI
Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth
Katharina M. Michalik,Xintian You,Yosif Manavski,Anuradha Doddaballapur,Martin Zörnig,Thomas Braun,David John,Yuliya Ponomareva,Wei Chen,Shizuka Uchida,Reinier A. Boon,Stefanie Dimmeler +11 more
TL;DR: Silencing of MALAT1 tips the balance from a proliferative to a migratory endothelial cell phenotype in vitro, and its genetic deletion or pharmacological inhibition reduces vascular growth in vivo.
Journal ArticleDOI
The role of Bcl-2 family members in tumorigenesis.
TL;DR: Since several Bcl-2 homologues, in addition to influencing apoptotic behaviour, also impinge on cell cycle progression, it is discussed possible implications of this additional role for the expression of B cl-2 family members in tumor cells.
Journal ArticleDOI
The CD95 receptor: apoptosis revisited.
Marcus E. Peter,Ralph C. Budd,Julie Desbarats,Stephen M. Hedrick,Anne-Odile Hueber,M. Karen Newell,Laurie B. Owen,Richard M. Pope,Juerg Tschopp,Harald Wajant,David Wallach,Robert H. Wiltrout,Martin Zörnig,David H. Lynch +13 more
TL;DR: Evidence suggests that CD95 mediates not only apoptosis but also diverse nonapoptotic functions depending on the tissue and the conditions.
Journal ArticleDOI
Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis
Anne-Odile Hueber,Martin Zörnig,Martin Zörnig,Debbie Lyon,Debbie Lyon,Takashi Suda,Takashi Suda,Shigekazu Nagata,Gerard I. Evan,Gerard I. Evan +9 more
TL;DR: Findings link two apoptotic pathways previously thought to be independent and establish the dependency of Myc on CD95 signaling for its killing activity and suppress c-myc-induced apoptosis by also acting downstream of CD95.