S
Stefan O. Mueller
Researcher at National Institutes of Health
Publications - 9
Citations - 394
Stefan O. Mueller is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Estrogen receptor & Receptor. The author has an hindex of 6, co-authored 9 publications receiving 266 citations.
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Journal ArticleDOI
Mammary Gland Development in Adult Mice Requires Epithelial and Stromal Estrogen Receptor α
TL;DR: Analysis of mammary gland whole mounts showed that both stromal and epithelial ERα were required for complete mammary glands development in adult mice, however, when the mice were treated with high doses of estradiol (E2) an...
Journal ArticleDOI
Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2 : A phase 1 randomized clinical trial.
Peter G. Kremsner,P. Mann,Arne Kroidl,Isabel Leroux-Roels,Christoph Schindler,Julian J. Gabor,Mirjam Schunk,Geert Leroux-Roels,Jacobus J. Bosch,Rolf Fendel,Andrea Kreidenweiss,Thirumalaisamy P. Velavan,Mariola Fotin-Mleczek,Stefan O. Mueller,Gianluca Quintini,Oliver Schönborn‑Kellenberger,Dominik Vahrenhorst,Thomas Verstraeten,Margarida Alves de Mesquita,Lisa Walz,Olaf‑Oliver Wolz,Lidia Oostvogels +21 more
TL;DR: In this article, the authors used the RNActive technology platform (CureVac N.V., Tubingen, Germany) to prepare CVnCoV, a COVID-19 vaccine containing sequence-optimized mRNA coding for a stabilised form of SARS-CoV-2 spike (S) protein encapsulated in lipid nanoparticles (LNP).
Journal ArticleDOI
Optimization of Non-Coding Regions for a Non-Modified mRNA COVID-19 Vaccine.
Makda S. Gebre,Susanne Rauch,Nicole Roth,Jingyou Yu,Abishek Chandrashekar,Noe B. Mercado,Xuan He,Jinyan Liu,Katherine McMahan,Amanda J. Martinot,David R. Martinez,Tori Giffin,David L. Hope,Shivani A. Patel,Daniel Sellers,Owen Sanborn,Julia Barrett,Xiaowen Liu,Andrew C. Cole,Laurent Pessaint,Daniel Valentin,Zack Flinchbaugh,Jake Yalley-Ogunro,Jeanne Muench,Renita Brown,Anthony L. Cook,Elyse Teow,Hanne Leth Andersen,Mark G. Lewis,Adrianus C. M. Boon,Ralph S. Baric,Stefan O. Mueller,Benjamin Petsch,Dan H. Barouch,Dan H. Barouch +34 more
TL;DR: In this paper, a head-to-head study of the immunogenicity and protective efficacy of CVnCoV and CV2CoV in nonhuman primates was conducted.
Posted ContentDOI
mRNA based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus neutralizing antibodies and mediates protection in rodents
Susanne Rauch,Nicole Roth,Kim Ellen Schwendt,Mariola Fotin-Mleczek,Stefan O. Mueller,Benjamin Petsch +5 more
TL;DR: Preclinical data for clinical candidate CVnCoV, a lipid nanoparticle (LNP) encapsulated non-modified mRNA vaccine that encodes the full length, pre-fusion stabilised SARS-CoV-2 Spike (S) protein is shown, providing evidence that CVn coV represents a potent and safe vaccine candidate against Sars-Cov-2.
Book ChapterDOI
Mechanisms of Estrogen Receptor-Mediated Agonistic and Antagonistic Effects
TL;DR: The observed physiological effects are the result of a complex interplay between the estrogen receptor, its ligand, co-regulators, and other cell signaling pathways dependent on the target tissue, as well as the cellular and genetic environment.