S
Stefanie Schlierf
Researcher at Boston Children's Hospital
Publications - 5
Citations - 619
Stefanie Schlierf is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 5, co-authored 5 publications receiving 608 citations. Previous affiliations of Stefanie Schlierf include Ghent University Hospital.
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Journal Article
Deep sequencing reveals differential expression of microRNAs in favourable versus unfavourable neuroblastoma
Johannes H. Schulte,Tobias Marshall,Marcel Martin,Philipp Rosenstiel,Pieter Mestdagh,Stefanie Schlierf,Theresa Thor,Jo Vandesompele,Angelika Eggert,Stefan Schreiber,Sven Rahmann,Alexander Schramm +11 more
TL;DR: In-depth sequence analysis revealed extensive post-transcriptional miRNA editing in Neuroblastoma patients, and the putative tumor suppressive microRNAs, miR-542-5p and mi-628, were expressed in favorable NBs and virtually absent in unfavorable NBs.
Journal ArticleDOI
Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma
Johannes H. Schulte,Tobias Marschall,Marcel Martin,Philipp Rosenstiel,Pieter Mestdagh,Stefanie Schlierf,Theresa Thor,Jo Vandesompele,Angelika Eggert,Stefan Schreiber,Sven Rahmann,Alexander Schramm +11 more
TL;DR: In this paper, the authors analyzed the small RNA transcriptomes of five favorable and five unfavorable NBs using SOLiD next-generation sequencing, generating a total of >188 000 000 reads.
Journal ArticleDOI
MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors
Pieter Mestdagh,Erik Fredlund,Filip Pattyn,Johannes H. Schulte,Daniel Muth,Joëlle Vermeulen,Candy Kumps,Stefanie Schlierf,K. De Preter,N. Van Roy,Rosa Noguera,Genevieve Laureys,Alexander Schramm,Angelika Eggert,Frank Westermann,Franki Speleman,Jo Vandesompele +16 more
TL;DR: A widespread correlation between miRNA activation and c-MYC/MYCN-mediated coding gene expression modulation is uncovered and further substantiate the overlapping functions of c- MYC and MYCN in the process of tumorigenesis.
Journal ArticleDOI
Accurate prediction of neuroblastoma outcome based on miRNA expression profiles
Johannes H. Schulte,Benjamin Schowe,Pieter Mestdagh,Lars Kaderali,Prabhav Kalaghatgi,Stefanie Schlierf,Joëlle Vermeulen,Bent Brockmeyer,Kristian W. Pajtler,Theresa Thor,Katleen De Preter,Franki Speleman,Katharina Morik,Angelika Eggert,Jo Vandesompele,Alexander Schramm +15 more
TL;DR: It is concluded that neuroblastoma patient outcome prediction using miRNA expression is feasible and effective and studies testing miRNA‐based predictors in comparison to and in combination with mRNA and aCGH information should be initiated.
Journal ArticleDOI
MicroRNAs in the pathogenesis of neuroblastoma.
Johannes H. Schulte,Sebastian Horn,Sebastian Horn,Stefanie Schlierf,Alexander Schramm,Lukas C. Heukamp,Holger Christiansen,Reinhard Buettner,Bernd Berwanger,Angelika Eggert +9 more
TL;DR: The most recent attempts aiming to analyze the functional roles of microRNAs in neuroblastoma, the most devastating solid tumor in childhood, are reviewed.