S
Stella Pelengaris
Researcher at University of Warwick
Publications - 38
Citations - 3535
Stella Pelengaris is an academic researcher from University of Warwick. The author has contributed to research in topics: Cancer & Apoptosis. The author has an hindex of 20, co-authored 38 publications receiving 3295 citations. Previous affiliations of Stella Pelengaris include Lincoln's Inn.
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Journal ArticleDOI
c-MYC: more than just a matter of life and death.
TL;DR: Regulatable transgenic mouse models of oncogenesis have shed light on the role of c-MYC in tumour progression and provide hope for effective cancer therapies.
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Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression
TL;DR: The data indicate that highly complex neoplastic lesions can be both induced and maintained in vivo by a simple combination of two interlocking molecular lesions.
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Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion.
TL;DR: In this article, a targeted expression of a switchable form of the c-Myc protein to the skin epidermis, a well characterized homeostatic tissue, was shown to rapidly trigger proliferation and disrupts differentiation of postmitotic keratinocytes.
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The many faces of c-MYC.
Stella Pelengaris,Michael Khan +1 more
TL;DR: Encouraging results have been reported for several approaches using gene targeting to interfere with c-MYC expression or activity both in vitro and in vivo, raising the possibility that c-Myc may be a key contributor to disease, not only by deregulating cell proliferation, which is well established, but also by virtue of its opposing role in engendering apoptosis.
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Action of Myc in vivo - proliferation and apoptosis.
TL;DR: It is demonstrated that the balance between oncogene-induced proliferation and apoptosis in a given tissue can be a critical determinant in the initiation and maintenance of the tumor.