Stella Protopapas

TL;DR: The data suggest that implantation in eutherians is derived from an ancestral inflammatory reaction to embryo attachment in the therian ancestor, and the ability to shift from an inflammatory attachment reaction to a noninflammatory period of pregnancy was a key innovation in e Lutherian mammals that allowed an extended period of intimate placentation.

TL;DR: While the uterus exhibits programmed changes after ovulation, its transcriptional landscape during pregnancy responds to the presence of a fetus and upregulates genes that may be essential for fetal support, suggest results are consistent with endometrial recognition of pregnancy occurring in the opossum.

TL;DR: The patterns of gene expression in eutherian (placental) mammals are consistent with the notion that an increase in the E/P4 signaling ratio is critical for cervical ripening, and a tendency for decreased expression of progesterone receptor co-activators towards term is a shared derived feature of eutherians, suggesting that parturition is associated with broad scale histone de-acetylation.

TL;DR: It is argued that, in opossums, endometrial inflammation follows attachment of the embryo to the uterine wall, and that inflammatory signaling seen at implantation in eutherians evolved from this attachment-induced inflammation.

TL;DR: In this paper , the authors investigated the correlation of community poverty level and other social determinants of health with the persistence of moderate to severe disease activity and functional disability over the first year of treatment in pJIA patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry.