K
Katherine James
Researcher at Northumbria University
Publications - 56
Citations - 788
Katherine James is an academic researcher from Northumbria University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 12, co-authored 47 publications receiving 579 citations. Previous affiliations of Katherine James include American Museum of Natural History & Newcastle University.
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Journal ArticleDOI
A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome
Katherine James,S Al-Ali,S Al-Ali,Jessica Tarn,Simon Cockell,Colin S. Gillespie,Victoria Hindmarsh,James Locke,Sheryl Mitchell,Dennis Lendrem,Simon J. Bowman,Elizabeth Price,Colin T. Pease,Paul Emery,Peter Lanyon,John Hunter,Monica Gupta,Michele Bombardieri,Nurhan Sutcliffe,Costantino Pitzalis,John McLaren,Annie Cooper,Marian Regan,Ian Giles,David A. Isenberg,Vadivelu Saravanan,David Coady,Bhaskar Dasgupta,Neil McHugh,Steven Young-Min,Robert J. Moots,N Gendi,Mohammed Akil,Bridget Griffiths,Anil Wipat,Julia L. Newton,Julia L. Newton,David Jones,John D. Isaacs,John D. Isaacs,Jennifer Hallinan,Wan-Fai Ng,Wan-Fai Ng +42 more
TL;DR: Systematic analysis of gene expression data from pSS patients discordant for fatigue identified 55 genes which are predictive of fatigue level using SVM classification, which represents the first step in understanding the underlying pathophysiological mechanisms of fatigue in patients with pSS.
Journal ArticleDOI
Symptom-based stratification of patients with primary Sjögren’s syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials
Tarn,Nadia Howard-Tripp,Nadia Howard-Tripp,Dennis Lendrem,Xavier Mariette,A Saraux,Devauchelle-Pensec,Raphaèle Seror,Andrew J. Skelton,Katherine James,Peter McMeekin,S Al-Ali,S Al-Ali,Katie Hackett,Katie Hackett,BC Lendrem,Ben Hargreaves,Ben Hargreaves,John Casement,Sheryl Mitchell,Simon J. Bowman,Elizabeth Price,Colin T. Pease,Paul Emery,Peter Lanyon,John Hunter,Monisha Gupta,Michele Bombardieri,Nurhan Sutcliffe,Costantino Pitzalis,John McLaren,Annie Cooper,M Regan,Ian Giles,David A. Isenberg,Saravanan,David Coady,Bhaskar Dasgupta,Neil McHugh,Steven Young-Min,Robert J. Moots,N Gendi,M Akil,Bridget Griffiths,Sja Johnsen,KB Norheim,R Omdal,Deborah Stocken,Colin C Everett,Catherine Fernandez,John D. Isaacs,John D. Isaacs,J.-E. Gottenberg,J.-E. Gottenberg,Wan-Fai Ng,Wan-Fai Ng,French, Assess, cohort,Uk, Primary, Sjogren's, Syndrome, Registry +57 more
TL;DR: A robust method for stratification on the basis of patient-reported symptoms of patients with primary Sjögren's syndrome revealed distinct pathobiological endotypes with distinct responses to immunomodulatory treatments.
Journal ArticleDOI
Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability
Jennifer Munkley,Daniel Vodak,Karen E. Livermore,Katherine James,Brian T. Wilson,Brian T. Wilson,Bridget A. Knight,Paul McCullagh,John S. McGrath,Malcolm Crundwell,Lorna W. Harries,Hing Y. Leung,Craig N. Robson,Ian G. Mills,Ian G. Mills,Prabhakar Rajan,David J. Elliott +16 more
TL;DR: This study identifies gly cosylation as a global target for androgen control, and suggests loss of specific glycosylation enzymes might contribute to tumour regression following androgen depletion therapy.
Journal ArticleDOI
Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons
Andrew Best,Katherine James,Caroline Dalgliesh,Elaine Hong,Mahsa Kheirolahi-Kouhestani,Tomaz Curk,Yaobo Xu,Marina Danilenko,Rafiq Hussain,Bernard Keavney,Anil Wipat,Roscoe Klinck,Ian G. Cowell,Ka Cheong Lee,Caroline A. Austin,Julian P. Venables,Benoit Chabot,Mauro Santibanez Koref,Alison Tyson-Capper,David J. Elliott +19 more
TL;DR: Dual Tra2 protein depletion reduces expression of full-length CHK1 protein, results in the accumulation of the DNA damage marker γH2AX and decreased cell viability, and Tra2 proteins jointly control constitutive and alternative splicing patterns via paralog compensation to control pathways essential to the maintenance of cell viability.
Journal ArticleDOI
The gene-rich genome of the scallop Pecten maximus
Nathan J. Kenny,Shane A. McCarthy,Olga Dudchenko,Olga Dudchenko,Katherine James,Emma Betteridge,Craig Corton,Jale Dolucan,Dan Mead,Karen Oliver,Arina D. Omer,Sarah Pelan,Yan Ryan,Yan Ryan,Ying Sims,Jason Skelton,Michelle Smith,James Torrance,David Weisz,Anil Wipat,Erez Lieberman Aiden,Kerstin Howe,Suzanne T. Williams +22 more
TL;DR: The genome assembly of P. maximus and its annotated gene set provide a high-quality platform for studies on such disparate topics as shell biomineralization, pigmentation, vision, and resistance to algal toxins.