S
Susan M. Goodman
Researcher at Hospital for Special Surgery
Publications - 195
Citations - 7363
Susan M. Goodman is an academic researcher from Hospital for Special Surgery. The author has contributed to research in topics: Medicine & Rheumatoid arthritis. The author has an hindex of 32, co-authored 159 publications receiving 5142 citations. Previous affiliations of Susan M. Goodman include University of Arizona & Columbia University.
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Journal ArticleDOI
Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet
Jaime Uribarri,Sandra Woodruff,Susan M. Goodman,Weijing Cai,Xue Chen,Renata Pyzik,Angie Yong,Gary E. Striker,Helen Vlassara +8 more
TL;DR: The formation of new dAGEs during cooking was prevented by the AGE inhibitory compound aminoguanidine and significantly reduced by cooking with moist heat, using shorter cooking times, cooking at lower temperatures, and by use of acidic ingredients such as lemon juice or vinegar.
Journal ArticleDOI
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Deepak A. Rao,Michael F. Gurish,Jennifer L. Marshall,Kamil Slowikowski,Chamith Y. Fonseka,Yanyan Liu,Laura T. Donlin,Lauren A. Henderson,Kevin Wei,Fumitaka Mizoguchi,Nikola Teslovich,Nikola Teslovich,Michael E. Weinblatt,Elena Massarotti,Jonathan S. Coblyn,Simon M. Helfgott,Yvonne C. Lee,Derrick J. Todd,Vivian P. Bykerk,Susan M. Goodman,Susan M. Goodman,Alessandra B. Pernis,Lionel B. Ivashkiv,Elizabeth W. Karlson,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,James A. Lederer,Soumya Raychaudhuri,Michael B. Brenner +30 more
TL;DR: Using multidimensional cytometry, transcriptomics, and functional assays, a population of PD-1hiCXCR5− ‘peripheral helper’ T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF are defined.
Journal ArticleDOI
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.
Fan Zhang,Kevin Wei,Kamil Slowikowski,Chamith Y. Fonseka,Deepak A. Rao,Stephen Kelly,Susan M. Goodman,Susan M. Goodman,Darren Tabechian,Laura B. Hughes,Karen Salomon-Escoto,Gerald F. Watts,A. Helena Jonsson,Javier Rangel-Moreno,Nida Meednu,Cristina Rozo,William Apruzzese,Thomas Eisenhaure,David J. Lieb,David L. Boyle,Arthur M. Mandelin,Brendan F. Boyce,Edward F. DiCarlo,Ellen M. Gravallese,Peter K. Gregersen,Larry W. Moreland,Gary S. Firestein,Nir Hacohen,Chad Nusbaum,James A. Lederer,Harris Perlman,Costantino Pitzalis,Andrew Filer,V. Michael Holers,Vivian P. Bykerk,Vivian P. Bykerk,Laura T. Donlin,Laura T. Donlin,Jennifer H. Anolik,Michael B. Brenner,Soumya Raychaudhuri +40 more
TL;DR: Several single-cell -omics approaches are used to define the cellular processes and pathways in the human RA joint and attributed IL6 expression to THY1+HLA-DRAhi fibroblasts and IL1B production to pro-inflammatory monocytes, potentially key mediators of RA pathogenesis.
Journal ArticleDOI
Circulating Glycotoxins and Dietary Advanced Glycation Endproducts: Two Links to Inflammatory Response, Oxidative Stress, and Aging
Jaime Uribarri,Weijing Cai,Melpomeni Peppa,Susan M. Goodman,Luigi Ferrucci,Gary E. Striker,Helen Vlassara +6 more
TL;DR: Circulating indicators of AGEs (CML and MG derivatives), although elevated in older participants, correlate with indicators of inflammation and OS across all ages, and reduced consumption of these oxidants may prove a safe economic policy to prevent age-related diseases, especially in an aging population.
Journal ArticleDOI
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
Fumitaka Mizoguchi,Kamil Slowikowski,Kevin Wei,Jennifer L. Marshall,Deepak A. Rao,Sook Kyung Chang,Hung N. Nguyen,Erika H. Noss,Erika H. Noss,Jason D. Turner,Brandon E. Earp,Philip E. Blazar,John Wright,Barry P. Simmons,Laura T. Donlin,George D. Kalliolias,Susan M. Goodman,Susan M. Goodman,Vivian P. Bykerk,Vivian P. Bykerk,Lionel B. Ivashkiv,Lionel B. Ivashkiv,James A. Lederer,Nir Hacohen,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,Soumya Raychaudhuri,Michael B. Brenner +29 more
TL;DR: Functional and transcriptional differences between fibroblast subsets from human synovial tissues are shown using bulk transcriptomics of targeted subpopulations and single-cell transcriptomics for rheumatoid arthritis.