S
Stephan A. Grupp
Researcher at Children's Hospital of Philadelphia
Publications - 396
Citations - 44427
Stephan A. Grupp is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Chimeric antigen receptor & Transplantation. The author has an hindex of 77, co-authored 366 publications receiving 34450 citations. Previous affiliations of Stephan A. Grupp include University of Pennsylvania & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies.
Varun V. Prabhu,Mala K. Talekar,Amriti R. Lulla,C. Leah B. Kline,Lanlan Zhou,Junior Hall,A. Pieter J. van den Heuvel,David T. Dicker,Jawad Babar,Stephan A. Grupp,Mathew J. Garnett,Ultan McDermott,Cyril H. Benes,Jeffrey J. Pu,David F. Claxton,Nadia Khan,Wolfgang Oster,Joshua E. Allen,Wafik S. El-Deiry +18 more
TL;DR: Results serve as a rationale for ONC201 single-agent trials in relapsed/refractory acute leukemia, non-Hodgkin's lymphoma, MM and combination trial with dexamethasone in MM, provide pharmacodynamic biomarkers and identify further synergistic combinatorial regimens that can be explored in the clinic.
Journal ArticleDOI
Lingering effects of chemotherapy on mature T cells impair proliferation.
TL;DR: It is observed that surviving T cells could be stimulated, expanded, and transduced with CARs with preserved short-term cytolytic function but at far lower numbers and with residual metabolic deficits.
Journal ArticleDOI
Toxicities of busulfan/melphalan versus carboplatin/etoposide/melphalan for high-dose chemotherapy with stem cell rescue for high-risk neuroblastoma.
Ami V. Desai,Mallorie B. Heneghan,Yimei Li,Yimei Li,Nancy Bunin,Nancy Bunin,Stephan A. Grupp,Rochelle Bagatell,Rochelle Bagatell,Alix E. Seif,Alix E. Seif +10 more
TL;DR: The optimal autologous stem cell rescue (HDC-SCR) regimen for children with high-risk neuroblastoma (HR-NBL) is not defined as mentioned in this paper.
Journal ArticleDOI
Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL
Caroline Diorio,Ryan Murray,Mark Naniong,L. Barrera,Adam Camblin,J. Chukinas,Lindsey Coholan,Aaron Edwards,Tori Fuller,Claudia Gonzales,Stephan A. Grupp,Alden Ladd,Melissa Le,Angelica Messana,Faith Musenge,Haley Newman,Yeh Chuin Poh,Henry Poulin,Theresa Ryan,Rawan Shraim,Sarah K. Tasian,Tiffaney Vincent,Lauren Young,Yong Zhang,Giuseppe Ciaramella,Jason Michael Gehrke,David T. Teachey +26 more
TL;DR: CBE is a promising technology for applications requiring multiplexed gene editing and can be used to manufacture quadruple-edited 7CAR8 cells with high potential for clinical translation for relapsed and refractory T-ALL.
Journal ArticleDOI
Rapid-sequence tandem transplant for children with high-risk neuroblastoma.
Stephan A. Grupp,Julie W. Stern,Nancy Bunin,Cheryl Medeiros Nancarrow,Roberta H. Adams,Jed B. Gorlin,Greg Griffin,Lisa Diller +7 more
TL;DR: This work demonstrates that a tandem transplant regimen for high-risk NB is a feasible treatment strategy in children and may improve disease-free survival.