S
Stephan A. Grupp
Researcher at Children's Hospital of Philadelphia
Publications - 396
Citations - 44427
Stephan A. Grupp is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Chimeric antigen receptor & Transplantation. The author has an hindex of 77, co-authored 366 publications receiving 34450 citations. Previous affiliations of Stephan A. Grupp include University of Pennsylvania & St. Jude Children's Research Hospital.
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Therapeutic regimens for chimeric antigen receptor therapies
Stephen J. Schuster,Lamis Eldjerou,John P. Plastaras,William Tristram Arscott,Stephan A. Grupp +4 more
TL;DR: In this article, a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule.
Journal ArticleDOI
Treatment of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) Post-Hematopoietic Stem Cell Transplantation (HSCT) in Patients with Acute Leukemias: A Subgroup Analysis from the Defibrotide Expanded-Access Program
Paul G. Richardson,Angela R. Smith,Brandon M. Triplett,Nancy A. Kernan,Stephan A. Grupp,Stephan A. Grupp,Joseph H. Antin,Leslie Lehmann,Wei Liang,Robin Hume,William Tappe,Robert J. Soiffer +11 more
TL;DR: Here, Day +100 post-HSCT survival and safety are analyzed for the 2 largest primary-disease subgroups in that study: acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and the expanded-access program, including patients with or without MOD.
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CD22-Targeted CAR-Modified T-Cells Safely Induce Remissions in Children and Young Adults with Relapsed, CD19-Negative B-ALL after Treatment with CD19-Targeted CAR T-Cells
Regina M. Myers,Amanda M. DiNofia,Yi-min Li,Caroline Diorio,Richard Aplenc,Diane Baniewicz,Jennifer Brogdon,Colleen Callahan,Boris Engels,Joseph A. Fraietta,Vanessa E. Gonzalez,Emma Iannone,Allison Barz Leahy,Hongyan Liu,Susan McClory,Susan R. Rheingold,Gerald Wertheim,Lisa Anne-Marie Wray,Noelle V. Frey,Shannon L. Maude,Stephan A. Grupp +20 more
TL;DR: In this article , a novel CD22/4-1BB CAR construct with a short scFv linker (CART22-65s) was developed and investigated in a phase 1 study (NCT02650414).
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Subcutaneous Immunoglobulin Replacement Following CD19-Specific Chimeric Antigen Receptor-T Cell Therapy for B-Cell Acute Lymphoblastic Leukemia
Journal ArticleDOI
Cardiac effects of chimeric antigen receptor (CAR) T-cell therapy in children.
Danielle S. Burstein,Shannon L. Maude,Stephan A. Grupp,Heather Griffis,Joseph W. Rossano,Kimberly Y. Lin +5 more
TL;DR: Treatment with CAR T-cells targeting CD19 for pediatric leukemia has demonstrated significant efficacy with the principal toxicity being cytokine release syndrome (CRS), however, the total number of patients treated with these therapies has declined in recent years.